Taguchi method: artificial neural network approach for the optimization of high-efficiency microfluidic biosensor for COVID-19.

COVID-19 is a pandemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus is mainly spread by droplets, respiratory secretions, and direct contact. Caused by the huge spread of the COVID-19 epidemic, research is focused on the study of biosensors as it presents a rapid solution for reducing incidents and fatality rates.

Numerical simulation and optimization of AC electrothermal microfluidic biosensor for COVID-19 detection through Taguchi method and artificial network.

Microfluidic biosensors have played an important and challenging role for the rapid detection of the new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Previous studies have shown that the kinetic binding reaction of the target antigen is strongly affected by process parameters. The purpose of this research was to optimize the performance of a microfluidic biosensor using two different approaches: Taguchi optimization and artificial neural network (ANN) optimization.