[A case of type IIa early gastric cancer complicated with multiple endocrine cell micronests in pernicious anemia].

The patient, a 5-year-old male, was diagnosed as having pernicious anemia at our hospital in 1969. By means of an upper G-I series, he was found to have a gastric protruded lesion on the greater curvature of the upper corpus in 1983. After an endoscopic polypectomy, a type II a early gastric cancer was diagnosed which, histologically, showed a well-differentiated adenocarcinoma and a total gastrectomy was performed.

Comparison of carcinoembryonic antigen levels between portal and peripheral blood in patients with colorectal cancer. Correlation with histopathologic variables.

Correlation between carcinoembryonic antigen (CEA) levels of peripheral and portal blood, and eight histopathologic variables, was examined in 66 patients with colorectal cancer. The change in CEA levels in the portal blood of 40 patients during operation was also examined in relation to histopathologic variables. CEA levels of portal blood (with a mean of 26.

[Carcinoembryonic antigen (CEA) levels of peripheral and portal blood and tumor histopathology in colorectal cancer].

Correlation between CEA levels of peripheral and portal blood and 9 histopathologic variables were examined in 66 patients with colorectal cancer. CEA levels of portal blood (mean 26.6ng/ml and positive rate more than 5ng/ml, 59.

Augmentation of lymphokine-activated killer cell activity in vitro by aloctin A.

Culturing of mouse spleen cells with IL2-containing MLA144 conditioned medium (MLA144 CM) resulted in the induction of cells cytotoxic to syngeneic and allogeneic tumor cells in vitro. The cytotoxicity was markedly augmented by the presence of aloctin A (Alo A), a lectin having anti-tumor activity, during the assay for the cytotoxicity. The results of cytotoxicity assay after treatment with antisera and complement indicated that the killer cells mainly consisted of Thy 1+, Lyt 1-2-, asialo GM1-T cells.

Induction of nonspecific cell-mediated cytotoxic reactivity from non-immune spleen cells treated with aloctin A.

Culturing of mouse spleen cells with aloctin A (Alo A), a lectin having anti-tumor activity, resulted in the induction of cells cytotoxic to syngeneic and allogenic tumor cells in vitro. Alo A-induced killer cells could be generated from spleen cells of natural killer cell-deficient beige mice but not from those of T cell-deficient nude mice. The results of cytotoxicity assay after treatment with antisera plus complement indicated that the killer cells mainly consisted of Thy 1+, Lyt 1-2+, asialo GM1(1)-T cells.

[Mitotic activity of cancer cells and survival of gastric cancer patients].

An in vivo stathmokinetic method was used to analyze the mitotic activity of cancer cells from 43 gastric cancer patients. The mitotic activity was distributed between mitotic index (MI) 40.0% and MI 127.

Non-uniform effects of neurohumoral agents on the internal diameter in parallel and series arranged small arteries in rabbit hindlimb.

Using X-ray angiography, the internal diameter (ID) of 31 sites of arteries in the hindlimb, i.e., the iliac, main femoral, profundal femoral, circumflex femoral, saphenous, and popliteal arteries, was measured in anesthetized rabbits.

Lectins modulate prostaglandin E2 production by rat peritoneal macrophages.

The effect of Aloctin A (Alo A), a lectin having anti-inflammatory activities, on prostaglandin (PG) E2 production by activated rat peritoneal macrophages was compared with that of concanavalin A (Con A), wheat germ agglutinin (WGA), plsum sativum agglutinin (PSA) and soybean agglutinin (SBA). Alo A, WGA, Con A and PSA at 10 micrograms per ml inhibited PG E2 production. But SBA, even at a dose of 1 microgram per ml, stimulated PG E2 production.

[A clinicopathological study on hematogenous recurrence of colo-rectal cancer--with special reference to prediction and prevention of the recurrence].

Hematogenous recurrence was investigated in 325 cases of colo-rectal cancer. Hematogenous recurrence was confirmed in 34 cases including 25 liver, 5 lung, 2 bone, one brain and one skin recurrence. Most of the cases (28 cases, 82.

[A clinicopathological study on carcinoma of the gastric stump, with special reference to mucosal change].

Ten carcinomas of the gastric stump reconstructed by Billroth I (one case) and Billroth II (9 cases) methods were treated an average of 20 (range: 7-46) years after partial gastrectomy. Because of highly advanced carcinoma, total gastrectomy with resection of invaded organs was performed. The 5-year survival rate was 33%, and was not different from that in patients with carcinoma of the cardia.

Augmentation of natural cell-mediated cytotoxic reactivity of mouse lymphoid cells by aloctin A.

The levels of natural cell-mediated cytotoxicity could be augmented by administration of Aloctin A (Alo A), a lectin having anti-tumor activity. i.v.

Hemopexin levels in mice.

Using a simple measurement system of hemopexin, single radial immunodiffusion-plate, the following results were obtained; firstly the normal level of hemopexin concentration in mouse was 0.55-1.25 mg ml-1.

Pharmacological studies on a plant lectin aloctin A. II. Inhibitory effect of aloctin A on experimental models of inflammation in rats.

A glycoprotein, Aloctin A, which was isolated from Aloe arborescens Mill, markedly inhibits adjuvant arthritis in rats and carrageenin-induced edema in rats.

Blue dextran-mediated hemagglutination.

Blue dextran at low concentrations (0.1-1 ng/ml) agglutinated human, mouse, rabbit and rat erythrocytes. This agglutination was inhibited by 10% calf serum, 0.

Histochemical studies of lysosomal enzyme and nitroblue tetrazolium reduction of phagocytes in the cerebrospinal fluid of patients with infectious diseases of the central nervous system.

Lysosomal enzyme levels and nitroblue tetrazolium (NBT) reduction of phagocytes in the cerebrospinal fluid (CSF) of patients with infectious diseases of the central nervous system (CNS) were studied histochemically to evaluate the function of phagocytes. Lysosomal enzymes of acid phosphatase and beta-galactosidase were demonstrated in mononuclear phagocytes and leptomeningeal cells, but not in polymorphonuclear leukocytes (PMN) and lymphocytes. In tuberculous meningitis, more than 60% of the cells were positive for the enzymes as compared with less than 30% for other diseases.