Increasing plasma methadone concentrations are associated with decreased leukocyte oxidative burst without affecting cytokine production or phagocytosis in healthy dogs.

Objective: To determine whether methadone administration affects leukocyte phagocytic function, oxidative burst, and cytokine production and if immune function is associated with plasma methadone concentrations in dogs.

Methods: This was a prospective, randomized, placebo-controlled, nonblinded crossover study. Ten client-owned healthy dogs were included in the study.

Evaluation of Host Constitutive and Ex Vivo Coccidioidal Antigen-Stimulated Immune Response in Dogs with Naturally Acquired Coccidioidomycosis.

The early innate immune response to coccidioidomycosis has proven to be pivotal in directing the adaptive immune response and disease outcome in mice and humans but is unexplored in dogs. The objectives of this study were to evaluate the innate immune profile of dogs with coccidioidomycosis and determine if differences exist based on the extent of infection (i.e.