Publications by authors named "Imane Morjane"
Article Synopsis
- - Obesity is a major global health issue, linked to environmental and genetic factors, particularly the leptin gene (LEP), and this study investigated specific gene variations (polymorphisms) related to obesity in Moroccans.
- - The researchers genotyped two specific polymorphisms (rs7799039 and rs11761556) in 146 obese patients and 104 controls using real-time PCR, analyzing the data with R programming.
- - The findings indicated no significant link between the tested polymorphisms and obesity risk, although there was a notable increase in triglyceride levels in certain genetic carriers, suggesting that these polymorphisms are not key genetic risk factors for obesity.
Background: Variants in the Hepatocyte Nuclear Factor 1 Alpha gene (HNF1A) are associated with lipoproteins levels and type 2 diabetes. In this study, we aimed to assess the association of HNF1A gene and haplotypes with the metabolic syndrome (MetS) and its components through an association study in the Tunisian population as well as by a meta-analysis.
Methods: A total of 594 Tunisian individuals were genotyped for three variants (rs1169288, rs2464196 and rs735396) located in HNF1A gene using KASPar technology.
Purpose: Coronary artery diseases (CAD) are clinical cardiovascular events associated with dyslipidemia in common. The interaction between environmental and genetic factors can be responsible for CAD. The present paper aimed to examine the association between c.
View Article and Find Full Text PDFLeptin is a peptide hormone that regulates fat stores in the body and appetite by controlling the feeling of satiety. This hormone is secreted by the white adipose tissue and plays a role in the storage and mobilization of fatty acids. Mutations of the LEP gene have been associated with obesity in different populations; it is a multifactorial disease that constitutes a major public health problem.
View Article and Find Full Text PDFResistin () is a gene coding for proinflammatory adipokine called resistin secreted by macrophages in humans. Single nucleotide polymorphisms (SNPs) in are linked to obesity and insulin resistance in various populations. Using dbSNP, 78 nonsynonymous SNPs (nsSNPs) were retrieved and tested on a PredictSNP 1.
View Article and Find Full Text PDFAims: Variants in Hepatocyte Nuclear Factor 1 alpha (HNF1A) gene are associated with Metabolic Syndromeand its components independently. In this study, we aimed to assess the statistical association of the rs1169288, rs2464196 and rs735396 variants and haplotypes of HNF1A gene with metabolic syndrome (MS) and its components in a Moroccan population sample.
Methods: Three variants in the HNF1A gene were genotyped, rs1169288 A>C, rs2464196 G>A and rs735396 T>C in cases and controls from Moroccan population using KASPar technology (KBioscience, UK).