Publications by authors named "Imane Gamgami"
Article Synopsis
- Respiratory viruses like influenza and coronaviruses infect the body through the upper respiratory tract, where the resident microbiome plays a protective role.
- The study explores the use of a throat spray containing live lactobacilli probiotics as a potential prevention and treatment method for these viral infections, focusing on their antiviral and immunostimulatory properties.
- Three specific strains of lactobacilli were selected and showed promise by significantly reducing the effects of various respiratory viruses in lab models, while also maintaining their effectiveness when formulated into a throat spray for human testing.
Primary care urgently needs treatments for coronavirus disease 2019 (COVID-19) patients because current options are limited, while these patients who do not require hospitalization encompass more than 90% of the people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we evaluated a throat spray containing three strains with broad antiviral properties in a randomized, double-blind, placebo-controlled trial. Before the availability of vaccines, 78 eligible COVID-19 patients were randomized to verum ( = 41) and placebo ( = 37) within 96 h of a positive PCR-based SARS-CoV-2 diagnosis, and a per-protocol analysis was performed.
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