DeepCTG® 2.0: Development and validation of a deep learning model to detect neonatal acidemia from cardiotocography during labor.

Cardiotocography (CTG) is the main tool available to detect neonatal acidemia during delivery. Presently, obstetricians and midwives primarily rely on visual interpretation, leading to a significant intra-observer variability. In this paper, we build and evaluate a convolutional neural network to detect neonatal acidemia from the CTG signals during delivery on a multicenter database with 27662 cases in five centers, including 3457 and 464 cases of moderate and severe neonatal acidemia respectively (defined by a fetal pH at birth between 7.

Large-scale analysis of interobserver agreement and reliability in cardiotocography interpretation during labor using an online tool.

Background: While the effectiveness of cardiotocography in reducing neonatal morbidity is still debated, it remains the primary method for assessing fetal well-being during labor. Evaluating how accurately professionals interpret cardiotocography signals is essential for its effective use. The objective was to evaluate the accuracy of fetal hypoxia prediction by practitioners through the interpretation of cardiotocography signals and clinical variables during labor.

DeepCTG® 1.0: an interpretable model to detect fetal hypoxia from cardiotocography data during labor and delivery.

Introduction: Cardiotocography, which consists in monitoring the fetal heart rate as well as uterine activity, is widely used in clinical practice to assess fetal wellbeing during labor and delivery in order to detect fetal hypoxia and intervene before permanent damage to the fetus. We present DeepCTG® 1.0, a model able to predict fetal acidosis from the cardiotocography signals.

Computerized cardiotocography analysis during labor - A state-of-the-art review.

Cardiotocography is defined as the recording of fetal heart rate and uterine contractions and is widely used during labor as a screening tool to determine fetal wellbeing. The visual interpretation of the cardiotocography signals by the practitioners, following common guidelines, is subject to a high interobserver variability, and the efficiency of cardiotocography monitoring is still debated. Since the 1990s, researchers and practitioners work on designing reliable computer-aided systems to assist practitioners in cardiotocography interpretation during labor.

Impact of Crohn's disease on obstetrical management.

Objective: Patients with Crohn's disease (CD) may have perineal lesions or a history of anorectal surgery that raise concerns about complications during delivery resulting in a discussion of cesarean section. Our objective was to study the impact of CD on the mode of delivery.

Method: We conducted a retrospective study between 2005 and 2019 of the pregnancy outcomes of patients with CD.

Contribution of vaginal culture to predict early onset neonatal infection in preterm prelabor rupture of membranes.

Background: Preterm prelabor rupture of membranes (PPROM) is a major cause of morbidity and mortality for both the mother and the newborn. The vaginal germ profile in PPROM is poorly known, particularly regarding the risk of early-onset neonatal infection (EONI).

Objective: To determine microbiological risk factors for EONI in case of PPROM before 34 weeks of gestation (WG).

Retrospective Description of Pregnant Women Infected with Severe Acute Respiratory Syndrome Coronavirus 2, France.

Fix data are available on the management of pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We conducted a retrospective study of 100 pregnant women with SARS-CoV-2 infection in 4 obstetric units in the Paris metropolitan area of France during March 12-April 13, 2020. Among patients, 52 (52%) were hospitalized, 10 (10%) in intensive care units (ICUs).

Antenatal diagnosis of absence of septum pellucidum.

The absence of septum pellucidum (ASP) is a rare disease, which affects the structure of the brain. It is either isolated or associated with various congenital brain malformations. The diagnosis of ASP can be performed by second-trimester ultrasound.

Managing the Unusual Causes of Fetal Anemia.

Background: Rare causes of fetal anemia requiring intrauterine transfusion (IUT) are challenging for fetal medicine specialists.

Objectives: The aim of this study was to describe the perinatal patterns and prognosis in a consecutive series of fetuses transfused for fetal anemia of rare or unknown etiology, and to propose a protocol of investigation for fetal anemia of undetermined cause and for the management of subsequent pregnancies.

Method: We conducted a retrospective descriptive study on fetuses transfused for severe anemia of rare or unknown etiology managed in our national referral center (Centre National de Référence d'Hémobiologie Périnatale) and born between 2010 and 2017.