Publications by authors named "Imane Aitraise"
Article Synopsis
- - The study highlights the significance of WHRN gene variants, which are linked to non-syndromic hearing loss and Usher syndrome type II, a condition affecting both hearing and vision.
- - Researchers conducted exome sequencing on a Moroccan patient with severe hearing loss, revealing a specific mutation (c.619G > T; p.Ala207Ser) in the WHRN gene, crucial for binding protein complexes in ear and eye cells.
- - Bioinformatics analysis and molecular modeling suggest that this mutation may alter the structure of the WHRN protein, potentially explaining the patient's hearing impairment.
One of the most prevalent sensorineural disorders, autosomal recessive non-syndromic hearing loss (ARNSHL) which can affect all age groups, from the newborn (congenital) to the elderly (presbycusis). Important etiologic, phenotypic, and genotypic factors can cause deafness. So far, the high genetic variability that explains deafness makes molecular diagnosis challenging.
View Article and Find Full Text PDFBackground: Deafness is the most prevalent human sensorineural defect. It may occur as a result of an external auditory canal involvement, or a deficiency in the sound conduction mechanism, or an impairment of the cochlea, the cochlear nerve or central auditory perception. The genetic causes are the most common, as approximately 70% of hearing disorders are of hereditary origin, divided into two groups, syndromic (associated with other symptoms) and no syndromic (isolated deafness).
View Article and Find Full Text PDFArticle Synopsis
- Eight viruses are classified as carcinogenic or probably carcinogenic to humans, including HPV, hepatitis B and C, EBV, HTLV-1, HHV-8, Merkel cell polyomavirus, and HIV-1.
- These viruses are linked to over 14,000 cancer cases annually in Morocco, but not everyone infected will develop cancer.
- Host genetic factors and lifestyle choices could influence the risk of cancer, suggesting that understanding these interactions may help in early detection and prevention strategies.