Publications by authors named "Iman M Ouda"
Identification of Fhit as a post-transcriptional effector of Thymidine Kinase 1 expression.
Biochim Biophys Acta Gene Regul Mech
March 2017
FHIT is a genome caretaker gene that is silenced in >50% of cancers. Loss of Fhit protein expression promotes accumulation of DNA damage, affects apoptosis and epithelial-mesenchymal transition, though molecular mechanisms underlying these alterations have not been fully elucidated. Initiation of genome instability directly follows Fhit loss and the associated reduced Thymidine Kinase 1 (TK1) protein expression.
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- * Research on Fhit-deficient mouse models has shown a significant increase in genetic mutations, including single-base substitutions, which resembles mutation patterns found in human cancers like kidney, esophageal, and bladder cancers.
- * The mutation patterns may be linked to an imbalance in nucleotide pools due to low thymidine kinase 1 expression, alongside evidence suggesting that specific treatments can induce further mutations in Fhit-deficient cells.