Prognostic value of p27 in follicular thyroid carcinoma and its relation to radioactive iodine response: does it aid in the modification of risk stratification?

Introduction: Follicular thyroid carcinoma (FTC) is the second most common type of thyroid cancer. Genetic studies have demonstrated that the loss of expression and function of Cdk inhibitor p27 leads to the development of multiple-organ hyperplasia and malignancy, including thyroid carcinoma.

Aim Of Work: (1) To assess the prognostic value of the quantitative expression of p27 in correlation with clinicopathologic prognostic indicators in FTC.

Value of immunohistochemical expression of p27 and galectin-3 in differentiation between follicular adenoma and follicular carcinoma.

Introduction: Thyroid neoplasms represent a broad spectrum of tumors with different biologic behaviors. Follicular neoplasms are classified as benign or malignant depending on the presence or absence of capsular and/or vascular invasion; however, evaluation of these features can be challenging on histopathologic examination. Galectin-3 is a member of lectin family and seems to play a significant role in a number of biological processes.