Collection of Time Activity Data to Support Exposure Assessment: Protocol for a Systematic Evidence Map.

Background: Time Activity Data (TAD) describe the timing, duration, and/or frequency of human activities. Given that activity dictates the rate of contact a person has with an environmental agent, activity data can be used to derive rigorous estimates of exposure. TAD has been used to support exposure estimation in a variety of contexts, although there has been no systematic characterization of how TAD has been collected for environmental health applications.

Entinostat as a combinatorial therapeutic for rhabdomyosarcoma.

Rhabdomyosarcoma (RMS) is the most common childhood soft tissue sarcoma. For the alveolar subtype (ARMS), the presence of the PAX3::FOXO1 fusion gene and/or metastases are strong predictors of poor outcome. Metastatic PAX3::FOXO1 ARMS often responds to chemotherapies initially, only to subsequently relapse and become resistant with most patients failing to survive beyond 8 years post-diagnosis.

Rotavirus infection of murine small intestine causes colonic secretion via age restricted galanin-1 receptor expression.

Background & Aims: Mechanisms for age restriction of rotavirus diarrhea are unclear. Because rotavirus primarily infects small intestine, colonic contribution has not been widely studied. Recent data suggest that colonic secretion postbacterial infection is mediated by galanin-1 receptors (Gal1-R).

The cytokine osteopontin modulates the severity of rotavirus diarrhea.

Osteopontin (OPN) is a sialated phosphoprotein found in tissues and secreted into body fluids. It is an integrin ligand with pleiotropic functions as an extracellular matrix protein in mineralized tissues and a cytokine that is active in cell signaling (A. B.