Publications by authors named "Iman Fawzy Montasser"
Article Synopsis
- Hepatocellular carcinoma (HCC) is the most common liver cancer, often caused by chronic hepatitis and cirrhosis, with this study aiming to examine the genomic characteristics of HCC in Egyptian patients through whole exome sequencing.
- Whole exome sequencing was performed on 13 HCC patients who underwent surgery, revealing specific mutational signatures and a set of highly mutated genes associated with HCC, including notable mutations in APOB and RP1L1 across multiple studies.
- The findings confirmed previously established patterns in HCC genetics, identifying critical signaling pathways and potential clinical targets, highlighting the importance of these mutations for future research and therapy development.
Background: Patients who undergo living donor liver transplantation (LDLT) may suffer complications that require intensive care unit (ICU) readmission.
Aim: To identify the incidence, causes, and outcomes of ICU readmission after LDLT.
Methods: A retrospective cohort study was conducted on patients who underwent LDLT.
Background And Study Aims: Portal vein thrombosis (PVT) is no longer an absolute contraindication for living donor liver transplantation (LDLT). This study aimed to assess the short-term outcomes of LDLT and compare the 1-year survival rates between patients with and without preoperative PVT.
Patients And Methods: This combined prospective and retrospective cohort study was conducted on patients who underwent LDLT at Ain Shams Centre for Organ Transplantation (ASCOT) between 2008 and 2020.
Background: Biliary complications (BCs) after liver transplantation (LT) remain a considerable cause of morbidity, mortality, increased cost, and graft loss.
Aim: To investigate the impact of BCs on chronic graft rejection, graft failure and mortality.
Methods: From 2011 to 2016, 215 adult recipients underwent right-lobe living-donor liver transplantation (RT-LDLT) at our centre.
Background: Despite significant advancements in liver transplantation (LT) surgical procedures and perioperative care, post-LT biliary complications (BCs) remain a significant source of morbidity, mortality, and graft failure. In addition, data are conflicting regarding the health-related quality of life (HRQoL) of LT recipients. Thus, the success of LT should be considered in terms of both the survival and recovery of HRQoL.
View Article and Find Full Text PDFBackground: The current SARS-CoV-2 pandemic may negatively impact the care of liver transplant candidates and recipients.
Main Body Of The Abstract: Accordingly, each country must have its national guidelines based on the current situation and according to available tools. Liver Transplantation Scientific Committee of Waiting List Project in Egypt was established in 13 April 2020.
What Is Known And Objective: The influence of immunosuppression on the response to antiviral therapy (AVT) for recurrent hepatitis C virus (HCV) infection in liver transplant (LT) recipients remains controversial, especially for the rarely investigated genotype 4. This study aims to compare the effects of the two widely used calcineurin inhibitors (CNIs) (cyclosporine A (CsA) and tacrolimus (Tac)) on the therapeutic response to different AVT regimens.
Methods: A prospective, dual-centre, cohort study of 126 Egyptian living donor liver transplant (LDLT) recipients with recurrent HCV genotype 4 infection, who were categorized into three groups according to the AVT used.
Background/aim: Portal vein tumor thrombosis (PVTT) is a common complication in hepatocellular carcinoma (HCC) and it was considered a relative contraindication for transarterial chemoembolization (TACE) by many centers. This study aimed to assess the outcomes after TACE in patients with branch PVT regarding Child classification, radiological response, and 1-year survival.
Methods: Thirty HCC patients (24 male, 6 females) Child A cirrhotics with branch PVT underwent TACE.
Meningitis is common in tropical areas and also in Egypt and has a world-wide distribution. This study evaluated the potential role of CSF TNF alpha in diagnosis and differenfial diagnosis of acute meningitis (bacterial versus asepic meningitis). This case-control study was conducted between Ain Shams University Tropical Medicine Department and Embaba Fever Hospital.
View Article and Find Full Text PDFObjective: Understanding issues pertaining to quality of life is essential for any disease, particularly in recipients of liver transplantation. The aim of this study was to evaluate the impact of liver transplantation on Egyptian recipients' health-related quality of life (HRQOL).
Methods: A prospective study carried out at the Ain Shams Center for Organ Transplantation (Cairo, Egypt), including 35 recipients for the evaluation of HRQOL using short form 36 score (Arabic version) and Beck Depression Inventory scores pre-transplantation and 1 and 6 months afterwards.
Objective: Early tumor recurrence, either local or intrahepatic distant recurrence (IDR), after successful radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) remains a significant problem. The study aimed to determine the potential risk factors for IDR within one year after successful RFA in HCC patients.
Methods: In total, 105 patients with 138 lesions who underwent RFA and were followed up for at least one year were included in this study.
Helicobacter pylori is a common and important transmissible bacterial human pathogen. Although several diagnostic tests are available for the detection of H. pylori infection, all of them have both advantages and disadvantages, and none can be considered as a single gold standard.
View Article and Find Full Text PDF