Publications by authors named "Ilya Strunilin"
Article Synopsis
- Despite extensive research on genomic changes in glioblastoma, the survival rate remains under 5% after five years.
- This study aims to broaden the understanding of high-grade glioma by combining various biological analyses (proteomics, metabolomics, etc.) to identify complex regulatory mechanisms involved in tumor growth and progression.
- Results from analysis of 228 tumors indicate significant variability in early-stage changes, but they converge on common outcomes affecting protein interactions and modifications, highlighting PTPN11's crucial role in high-grade gliomas.
Article Synopsis
- Aging is a significant risk factor in neurodegenerative diseases, and studying neuronal aging in controlled backgrounds can help understand the relationship between aging and neurodegeneration.
- In Huntington's disease, researchers found that the protein RCAN1 increases with age and its reduction can protect against neuron degeneration in affected individuals.
- Targeting RCAN1, either through genetic modification or the drug G2-115, enhances neuronal resilience by improving gene accessibility linked to longevity and autophagy.
Aging is a common risk factor in neurodegenerative disorders and the ability to investigate aging of neurons in an isogenic background would facilitate discovering the interplay between neuronal aging and onset of neurodegeneration. Here, we perform direct neuronal reprogramming of longitudinally collected human fibroblasts to reveal genetic pathways altered at different ages. Comparative transcriptome analysis of longitudinally aged striatal medium spiny neurons (MSNs), a primary neuronal subtype affected in Huntington's disease (HD), identified pathways associated with RCAN1, a negative regulator of calcineurin.
View Article and Find Full Text PDFIdentifying tumor-cell-specific markers and elucidating their epigenetic regulation and spatial heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA-seq and snATAC-seq in 34 and 28 human clear cell renal cell carcinoma (ccRCC) specimens, respectively, with matched bulk proteogenomics data. By identifying 20 tumor-specific markers through a multi-omics tiered approach, we reveal an association between higher ceruloplasmin (CP) expression and reduced survival.
View Article and Find Full Text PDFIn Drosophila, 50 classes of olfactory receptor neurons (ORNs) connect to 50 class-specific and uniquely positioned glomeruli in the antennal lobe. Despite the identification of cell surface receptors regulating axon guidance, how ORN axons sort to form 50 stereotypical glomeruli remains unclear. Here we show that the heterophilic cell adhesion proteins, DIPs and Dprs, are expressed in ORNs during glomerular formation.
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