Publications by authors named "Ilya I Brusentsov"
Background: Understanding genome organization and evolution is important for species involved in transmission of human diseases, such as mosquitoes. Anophelinae and Culicinae subfamilies of mosquitoes show striking differences in genome sizes, sex chromosome arrangements, behavior, and ability to transmit pathogens. However, the genomic basis of these differences is not fully understood.
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- Detailed study of phylogeography is crucial for managing mosquito species that spread diseases like malaria, particularly focusing on the two related species, Anopheles messeae and An. daciae.
- The research used ribosomal DNA analysis and karyotyping across 28 Eurasian locations to uncover genetic diversity and population structure, highlighting significant differences in their chromosomes and indicating limited gene flow between the species.
- Findings suggest that An. messeae has a more complex genetic makeup than An. daciae, with implications for understanding malaria transmission risk in various regions, particularly in northern Europe.
Article Synopsis
- GAGA (GAF) is a transcription factor crucial for regulating gene expression during fly development, and its underexpression in mutants leads to significant germline cell death and reduced testis size.
- Our RNA-seq analysis identified 2,437 differentially expressed genes in GAGA underexpressed testes, revealing downregulation of normal testis genes and an increase in stress-related genes.
- The study concludes that GAGA deficiency causes metabolic imbalances and impaired mitochondrial function, contributing to cellular stress and sperm cell death, but no specific GAGA-dependent cell death pathway was identified.
Article Synopsis
- The study investigates the genetic diversity of the Eurasian malaria vector, highlighting five significant chromosomal inversions found in its natural populations.
- Researchers identify a cryptic species distinguished by nucleotide substitutions in the ribosomal DNA's Internal Transcribed Spacer 2 (ITS2) region, though a complete reference cytogenetic map is lacking.
- A new cytogenetic map and ITS2-RFLP diagnostic method were developed, revealing notable differences in chromosomal inversion frequencies between the two species in a population from Western Siberia, with the main species exhibiting greater inversion polymorphism.
Article Synopsis
- The study investigates how noncoding genetic variations affect gene expression and their link to colorectal cancer (CRC).
- Researchers analyzed genetic data from 160 CRC patients and 185 healthy controls, focusing on six specific single nucleotide polymorphisms (SNPs) identified as potentially relevant to CRC.
- The findings reveal that certain SNPs show significant associations with CRC risk, with specific gender differences noted for rs590352 and rs4796672.