25-Hydroxyvitamin D concentrations, asthma and eczema in childhood: The generation R study.

Background & Aims: A role of vitamin D in the development of respiratory and allergic disease in children remains unclear. It may be likely that vitamin D has an effect on airway inflammation, but only few studies examined the effect in children. We aimed to examine whether serum 25-hydroxyvitamin D (25(OH) vitamin D) concentrations are associated with the fraction of exhaled nitric oxide (FeNO), airway interrupter resistance (Rint), physician diagnosed asthma ever, wheezing and eczema in a population-based cohort study in 6 year old children.

Infant feeding and anti-tissue transglutaminase antibody concentrations in the Generation R Study.

Background: Celiac disease (CD) has emerged as a common, but largely undiagnosed health problem. Numerous studies examined the influence of infant nutrition on the development of diagnosed CD. However, results are still inconsistent.

Dietary patterns and respiratory symptoms in pre-school children: the Generation R Study.

Overall diet in early childhood may affect the development of respiratory symptoms. This study examined whether childhood dietary patterns are associated with respiratory symptoms in Dutch pre-school children, and whether this association could be explained by energy intake. A prospective cohort study was performed in 2,173 children aged ≤ 4 yrs.

The introduction of allergenic foods and the development of reported wheezing and eczema in childhood: the Generation R study.

Objective: To examine whether the timing of introduction of the allergenic foods cow's milk, hen's egg, peanuts, tree nuts, soy, and gluten is associated with eczema and wheezing in children 4 years of age or younger.

Design: Population-based prospective cohort study from fetal life until young adulthood.

Setting: Rotterdam, the Netherlands, from April 2002 through January 2006.