Publications by authors named "Ilona R Kats"
Translating from cancer to the brain: regulation of protein synthesis by eIF4F.
Learn Mem
September 2019
Formation of eukaryotic initiation factor 4F (eIF4F) is widely considered to be the rate-limiting step in cap-dependent translation initiation. Components of eIF4F are often up-regulated in various cancers, and much work has been done to elucidate the role of each of the translation initiation factors in cancer cell growth and survival. In fact, many of the basic mechanisms describing how eIF4F is assembled and how it functions to regulate translation initiation were first investigated in cancer cell lines.
View Article and Find Full Text PDFArticle Synopsis
- Spinal and bulbar muscular atrophy (SBMA) is an X-linked neuromuscular disorder linked to an expanded CAG repeat in the androgen receptor gene.
- A unique case of a 29-year-old patient with 68 CAG repeats revealed early onset symptoms and additional issues not typically seen in SBMA patients.
- The study's findings highlight both typical SBMA deficits and novel manifestations, enhancing understanding of the disease's progression related to the mutated androgen receptor.
Article Synopsis
- Spinal and bulbar muscular atrophy (SBMA), also known as Kennedy's disease, is a motor neuron disease caused by an expansion of polyglutamine repeats in the androgen receptor, leading to degeneration in spinal cord and muscle, though its precise mechanism remains unclear.
- Induced pluripotent stem cells derived from SBMA patients serve as a valuable model for exploring disease mechanisms and potential therapies; these stem cells exhibited reduced androgen receptor expression but maintained the ability to stabilize and translocate to the nucleus in response to androgens.
- The findings suggest repeat instability, reduced HDAC6 levels, and altered acetylation patterns in motor neurons might provide new insights into SBMA’s pathology and highlight targets for future therapeutic strategies.