Publications by authors named "Ilona Polvoy"
Article Synopsis
- - The study focuses on vertebral discitis-osteomyelitis (VDO), a severe spinal infection that is tough to differentiate from noninfectious conditions using current imaging techniques.
- - Researchers tested various PET radiotracers in a rat model of VDO to see how well they could identify Staphylococcus aureus infections compared to Escherichia coli.
- - Results showed that [11C]PABA was the most effective tracer, able to detect low levels of bacteria and demonstrated a significant signal increase in infected tissues, suggesting potential for clinical application in human cases of VDO.
Imaging joint infections using D-methyl-C-methionine PET/MRI: initial experience in humans.
Eur J Nucl Med Mol Imaging
September 2022
Purpose: Non-invasive imaging is a key clinical tool for detection and treatment monitoring of infections. Existing clinical imaging techniques are frequently unable to distinguish infection from tumors or sterile inflammation. This challenge is well-illustrated by prosthetic joint infections that often complicate joint replacements.
View Article and Find Full Text PDFThe growing demand for metabolism-specific imaging techniques has rekindled interest in Deuterium (H) Metabolic Imaging (DMI), a robust method based on administration of a substrate (glucose, acetate, fumarate, etc.) labeled with the stable isotope of hydrogen and the observation of its metabolic fate in three-dimensions. This technique allows the investigation of multiple metabolic processes in both healthy and diseased states.
View Article and Find Full Text PDFIncreased mortality rates from infectious diseases is a growing public health concern. Successful management of acute bacterial infections requires early diagnosis and treatment, which are not always easy to achieve. Structural imaging techniques such as CT and MRI are often applied to this problem.
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