Publications by authors named "Ilona Liesche"
Biomed Pharmacother
November 2024
Article Synopsis
- Bone cells produce FGF23, a hormone that helps regulate phosphate and vitamin D levels, with elevated FGF23 linked to chronic kidney disease and cardiovascular issues.
- The study examined how Prostaglandin E (PGE), particularly through its receptor EP2, influences FGF23 production in bone cells, and found that PGE significantly enhances FGF23 levels.
- Using different mouse models, the research showed that PGE signaling through EP2 and the transcription factor Nurr1 is critical for FGF23 production, suggesting potential clinical implications for conditions involving inflammation and kidney health.
