Experimental testing of a prototype cantilevered liquid-nitrogen-cooled silicon mirror.

This report presents testing of a prototype cantilevered liquid-nitrogen-cooled silicon mirror. This mirror was designed to be the first mirror for the new soft X-ray beamlines to be built as part of the Advanced Light Source Upgrade. Test activities focused on fracture, heat transfer, modal response and distortion, and indicated that the mirror functions as intended.

Hypometric anticipatory postural adjustments in dystonia are not affected by deep brain stimulation of globus pallidus internus.

Background: Dystonia is a movement disorder with patterned, directional, and often sustained muscle contractions that produce abnormal postures or repetitive movements. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is an effective and safe treatment for medically refractory dystonia. However, recent studies reported gait problems, gait freezing and falls in patients treated with DBS.

[Cognitive Function in Patients Before and After Micro-neurosurgical Resection of Frontal Brain Tumors].

Patients with lesions of the prefrontal cortex as a result of frontal brain tumors (intra- and extra-axial) can show impairments of executive functions 1 2 3 4. Although there are a large number of psychological tests, the detection of impairments of relevant everyday executive functions in these patients is still extremely difficult. In 30 patients with lesions of the prefrontal cortex, the executive functions were tested with the Behavioral Assessment of Dysexecutive Syndrome (BADS) and 21 patients were also followed up postoperatively.

Dynamics of postural control in Parkinson patients with and without symptoms of freezing of gait.

Background: It has been suggested that dynamical measures such as sample entropy may be more appropriate than conventional measures when analyzing time series data such as postural sway. We evaluated conventional and dynamical measures of postural sway in Parkinson disease (PD) patients with and without freezing episodes.

Methods: COP (center of pressure) data were recorded during quiet standing with eyes open, eyes closed and while performing a dual task.

Visual cues combined with treadmill training to improve gait performance in Parkinson's disease: a pilot randomized controlled trial.

Objective: To evaluate the effects of visual cues combined with treadmill training on gait performance in patients with Parkinson's disease and to compare the strategy with pure treadmill training.

Design: Pilot, exploratory, non-blinded, randomized controlled trial.

Setting: University Hospital of Munich, Germany.

Postural stability under globus pallidus internus stimulation for dystonia.

Objective: Deep brain stimulation of the globus pallidus internus (GPi-DBS) is an efficient and safe treatment for medically refractory dystonia. However, recent studies reported gait problems, falls and bradykinesia in patients after the DBS procedure. The aim of this study was to quantify the effect of GPi-DBS on postural performance in patients with cranio-cervical dystonia.

Normative data for arm swing asymmetry: how (a)symmetrical are we?

Arm swing asymmetry during gait may be a sensitive sign for early Parkinson's disease. There is only very limited information about how much asymmetry can be considered to be physiological. To assess the normal range of arm swing asymmetry, we investigated 60 healthy subjects.

WITHDRAWN: Treatment outcome of visual feedback training in an adult patient with habitual toe walking.

Ahead of Print article withdrawn by publisher.

Validation of functional motor and language MRI with direct cortical stimulation.

Background: Functional magnetic resonance imaging (fMRI) is a widely available method and is therefore progressively utilized in neurosurgical practice. This study was carried out to determine fMRI sensitivity and specificity and to emphasize the threshold dependence of fMRI data.

Methods: A total of 17 consecutive patients, scheduled for surgery on intracerebral lesions near eloquent brain areas, underwent preoperative motor (N = 12) and language (N = 5) fMRI.

Differential effects of absent visual feedback control on gait variability during different locomotion speeds.

Healthy persons exhibit relatively small temporal and spatial gait variability when walking unimpeded. In contrast, patients with a sensory deficit (e.g.

Speed-dependent temporospatial gait variability and long-range correlations in cerebellar ataxia.

Objective: This study investigated the influence of impaired cerebellar locomotion function on the magnitude and structure of stride-to-stride fluctuations in the walking pattern. On the basis of studies reporting a dependency of variability magnitude and structure on the walking speed, we hypothesized that patients with cerebellar ataxia (CA) would show alterations of gait variability in a speed-dependent manner.

Methods: 11 patients with CA [7 idiopathic sporadic ataxia, 4 inherited spinocerebellar ataxia] and 11 healthy subjects (HS) walked on a treadmill for 5-min periods at their preferred walking speed and at 20%, 40%, 70%, and 80% of maximal walking speed.

Dynamic visual cueing in combination with treadmill training for gait rehabilitation in Parkinson disease.

Various cueing techniques as well as treadmill training have been shown to be effective in the gait rehabilitation of patients with Parkinson disease. We present a novel setup combining both dynamic visual cueing and body weight-supported treadmill training. A nonambulatory patient with Parkinson disease received six training sessions.

Pattern of local field potential activity in the globus pallidus internum of dystonic patients during walking on a treadmill.

The basal ganglia (BG) are involved in gait. This notion is exemplified by observations that gait is disturbed by most diseases that affect the BG. However, it is unclear in what way the BG are activated during gait.

The influence of essential oils on human vigilance.

Olfactory stimuli are used in aromatherapy to enhance mood, well-being and work efficiency. Nevertheless, the impact of fragrances on cognitive performance in humans is not well understood. The present investigation aimed to evaluate the effects of 1,8-cineol, jasmine absolute ether, linalyl acetate and peppermint essential oil on human vigilance performance.

Health-related quality of life and cognitive functioning in adult patients with supratentorial WHO grade II glioma: status prior to therapy.

The present prospective study intends to evaluate health-related quality of life (HRQL) and cognitive functioning in adult patients with supratentorial World Health Organization (WHO) grade II glioma (LGG) prior to observation/therapy and to determine possible influences of tumor-related factors on these measures. Adult patients with biopsy-proven supratentorial LGG were considered eligible (study period 18 months). Besides detailed documentation of patient clinical status we evaluated HRQL using the Short Form-36 (SF-36) Health Survey and applied the Beck Depression Inventory.

Dating problems with selected mining lakes and the adjacent groundwater body in Lusatia, Germany.

This study presents selected results, applying environmental tracers to investigate lake water-groundwater interactions at two study sites located in Lusatia, Germany. The focus of the investigations were two meromictic pit lakes and their adjacent aquifers. In order to follow hydrodynamic processes between lake and groundwater, mixing patterns within the lakes as well as ages of lake and groundwater, water samples of ground- and lake water were collected at three occasions, representing summer and winter conditions in the aquatic systems.

Sensitivity and reliability of language laterality assessment with a free reversed association task--a fMRI study.

Objective: The aim of the study was to evaluate the sensitivity and reliability of assessing hemispheric language dominance with functional magnetic resonance imaging (fMRI) using a 'free reversed association task.'

Methods: Thirty-nine healthy subjects (13 dextrals, 13 sinistrals and 13 bimanuals) underwent two repeated fMRI sessions. In the active phases sets of words were presented via headphones, and an associated target item was named.

Intraoperative mapping of language functions: a longitudinal neurolinguistic analysis.

Object: This prospective longitudinally designed study was conducted to evaluate language functions pre- and postoperatively in patients who underwent microsurgical treatment of tumors in close proximity to or within language areas and to detect those patients at risk for a postoperative aphasic disturbance.

Methods: Between 1991 and 2005, 153 awake craniotomies with subsequent cortical mapping of language functions were performed in 149 patients. Language functions were assessed using a standardized test battery.

Is the center of mass (COM) a reliable parameter for the localization of brain function in fMRI?

The center of mass (COM) in functional MRI studies is defined as the center of a cerebral activation cluster. Although the COM is a well-accepted parameter for exactly localizing brain function, the reliability of COMs has not received much attention until now. Our goal was to investigate COM reliability as a function of the thresholding technique, the threshold level, and the type of COM calculation.

Reproducibility of activations in Broca area with two language tasks: a functional MR imaging study.

Background And Purpose: Functional MR imaging (fMRI) is rapidly evolving and claims to complement or even substitute intraoperative mapping (IOM) of language functions. However, little is known about the reproducibility of imaging data in the language domain. The aim of our study was to assess the reproducibility of activations for 2 widely used paradigms: naming and word generation.

Reproducibility of activation in four motor paradigms. An fMRI study.

Most functional imaging data are collected in single session experiments; little is known about the reproducibility or test-retest reliability of the activation patterns found in these experiments. In our study, 15 healthy volunteers performed four simple motor-paradigms ("Hand", "Foot", "Mouth" and "Tongue") for functional magnetic resonance imaging (fMRI) in 3 sessions on different days. Reproducibility of activations in four anatomical regions (pre- and postcentral gyri, paracentral lobule and the supplementary motor area) was measured in terms of voxels active in all sessions (common voxels) relative to voxels active in single sessions, giving reliability coefficients from 0 to 1.

Surgical resection of gliomas WHO grade II and III located in the opercular region.

Background: Surgery in the opercular region especially in the dominant hemisphere impose a major challenge for the neurosurgeon due to the close vicinity to functional important motor and speech areas. The purpose of the present study is to analyse on a homogenous patient group pre- and postoperative functional deficits with regard to different speech qualities (e.g.

[Comparison of the Aachen Aphasia Test, clinical study and Aachen Aphasia Beside Test in brain tumor patients].

In the clinical routine examination of patients with brain tumors, aphasic symptoms are often not recognized. In order to document the incidence of such symptoms, three diagnostic methods of testing for aphasia were compared: the Aachen aphasia test (AAT), which is the German standard aphasia test, clinical examination, and the Aachen aphasia bedside test (AABT), which was designed to test patients in the acute phases of illness. In the AAT, 50% of patients with left-sided tumors and 36% of those with right-sided tumors showed aphasic disturbances.

Surgical resection of grade II astrocytomas in the superior frontal gyrus.

Objective: Surgery in the superior frontal gyrus partially involving the supplementary motor area (SMA) may be followed by contralateral transient weakness and aphasia initially indistinguishable from damage to the primary motor cortex. However, recovery is different, and SMA deficits may resolve completely within days to weeks. No study has assessed the distinct postoperative deficits after tumor resection in the SMA on a homogeneous patient group.