Publications by authors named "Illyane Sofia Lima"
Article Synopsis
- Severe malarial anemia (SMA) mainly affects children and pregnant women and is linked to impaired erythropoietin (EPO) signaling due to malaria infection.
- Research using a mouse model showed that while EPO levels rise in response to malaria, the production of red blood cells (RBC) in the spleen decreases significantly upon reinfection.
- The study also highlighted that an activated immune response in these animals correlates with increased SMA severity and impaired RBC production, emphasizing the strong link between immune function and erythropoiesis in SMA.
Parkinson's disease (PD) is a multifactorial neurodegenerative pathology characterized by the progressive loss of dopaminergic neurons in the substantia nigra of the brain. Aging is considered the main risk factor for the development of idiopathic PD. However, immunity and inflammation play a crucial role in the pathogenesis of this disorder.
View Article and Find Full Text PDFThere is still no cure for neurodegenerative diseases, such as Parkinson's disease (PD). Current treatments are based on the attempt to reduce dopaminergic neuronal loss, and multidisciplinary approaches have been used to provide only a temporary symptoms' relief. In addition to the difficulties of drugs developed against PD to access the brain, the specificity of those inhibitory compounds could be a concern.
View Article and Find Full Text PDF