Publications by authors named "Illolil Kuniyil Biju"
Article Synopsis
- Hepatitis A virus (HAV) usually causes mild illness but can lead to severe complications like acute liver failure, which is fatal in rare cases; in 2016, it resulted in about 7,134 deaths.
- Fulminant liver failure occurs in less than 1% of acute hepatitis A cases, but unusual associations with other severe conditions like haemophagocytic lymphohistiocytosis (HLH) have been noted.
- The case presented discusses a man in his 30s with G6PD deficiency, whose acute HAV infection led to severe symptoms, including hyperacute liver failure, HLH, and renal failure.
Methotrexate is one of the most commonly used drugs in autoimmune disorders like rheumatoid arthritis. Gastrointestinal symptoms like nausea and stomatitis, skin rashes, alopecia, central nervous system symptoms like headache and confusion, hepatotoxicity and myelosuppression are some of the adverse effects. However, low oral doses on a weekly basis seldom show any signs of toxicity.
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