Effect of acute administration of certain heavy metals and their combinations on the spontaneous and evoked cortical activity in rats.

The aim of this study was to see the effect of acutely administered inorganic lead, mercury, manganese, and their combinations, on the electrical activity in the somatosensory system of rats. Male Wistar rats were anaesthetised with urethane, the head was fixed in a stereotaxic frame and the left hemisphere was exposed. Weak electric shocks to the whiskers and the tail served as stimuli.

A study on electrophysiological effects of subchronic cadmium treatment in rats.

Male Wistar rats were treated for 4, 8 and 12 weeks with 3.5, 7.0 or 14.

Immunotoxicological investigation in rats dosed repeatedly with combinations of cypermethrin, As(III), and Hg(II).

The effects of the combined exposure of cypermethrin (CY), NaAsO2 (As), and HgCl2 (Hg) were investigated in male Wistar rats following 4 weeks of oral exposure. Standard toxicological (body weight gain, organ weights of brain, thymus, heart, lung, liver, kidneys, adrenals, testes, and popliteal lymph node), haematological (white blood cell, red blood cell, haematocrit, MCV-mean volume of red blood cells, and cell content of the femoral bone marrow), and immune function (IgM-PFC response, delayed type hypersensitivity (DTH) reaction) parameters were measured. The two doses selected for the combination were: a high (H) dose equal to lowest observed effect level determined in preliminary experiments (CY(H)=55.