Publications by authors named "Illary Sbizzera"
Objectives: We aimed to identify and evaluate: (1) treatment-emergent adverse events (TEAE (worse or new since baseline)) and the subgroup of severe TEAEs in a placebo-controlled 7-day randomised trial of regular, low-dose, sustained-release oral morphine for chronic breathlessness and (2) clinical characteristics associated with TEAE.
Methods: Safety analysis of trial data. Adults with chronic breathlessness (modified Medical Research Council breathlessness score ≥2) due to heart or lung disease, or cancer, not on regular opioids were eligible.
Article Synopsis
- Venous leg ulcers (VLUs) are challenging to treat, with a significant percentage not healing even after months of standard compression therapy, making the exploration of additional treatments like aspirin important.
- A pilot trial involving random assignments of chronic VLU patients to receive either 300 mg of daily aspirin or a placebo aimed to assess the efficacy, safety, and recruitment feasibility for future studies.
- The trial recruited 27 participants, but faced recruitment challenges, and ultimately found no significant difference in healing times between the aspirin and placebo groups, suggesting aspirin may not be effective for VLU treatment.
Participants not returning data collection questionnaires is a problem for many randomised controlled trials. The resultant loss of data leads to a reduction in statistical power and can result in bias. The aim of this study was to assess whether the use of a study update newsletter and/or a handwritten or printed Post-it® note sticker increased postal questionnaire response rates for participants of a randomised controlled trial.
View Article and Find Full Text PDFBackground: Venous leg ulcers (VLUs) are the most common cause of leg ulceration, affecting 1 in 100 adults. VLUs may take many months to heal (25% fail to heal). Estimated prevalence is between 1% and 3% of the elderly population.
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