Publications by authors named "Ilknur Tugal-Tutkun"

Intermediate uveitis is a relatively common form of intraocular inflammation that can be seen at any age. The vitreous is the primary site of inflammation; and the presence of snowballs or snowbank defines its subtype, pars planitis. Since it is a clinical diagnosis, it is important to recognize the typical clinical features and associated ocular complications.

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  • A 33-year-old male experienced vision loss in his right eye after developing hand, foot, and mouth disease, with accompanying vesicular lesions and oral ulcers.
  • Optical coherence tomography angiography (OCTA) revealed reduced blood flow in the choriocapillaris and bacillary layer detachment (BALAD) in the affected eye, indicating retinal issues.
  • The condition showed resolution in BALAD within two days, and choriocapillaris flow gradually improved over two months, suggesting a link between UAIM and systemic inflammation from the viral infection.
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Objectives: Behçet uveitis (BU) is a potentially blinding disorder. The main determinant of visual prognosis is early and appropriate treatment that provides rapid suppression of inflammatory attacks, control of subclinical inflammation, and prevention of new attacks. Our study aimed to determine the Turkish uveitis specialists' approach regarding the treatment choices and management of special situations such as pregnancy, vaccination, and surgical planning in BU patients, and to increase information sharing and raise awareness of issues where knowledge is lacking.

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We present a 20-year-old woman who was diagnosed with subacute sclerosing panencephalitis (SSPE) 20 months after presenting with unilateral retinitis. At presentation, the patient had two inferotemporal macular lesions in her left eye. Corresponding to these areas, optical coherence tomography (OCT) showed hyporeflective spaces with loss of nearly all of the retinal layers.

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  • The review updates the role of corticosteroids and immunomodulatory therapy (IMT) in treating infectious uveitis, focusing on managing inflammation rather than the infection itself.
  • Corticosteroids are mainly used alongside other treatments for infectious uveitis, especially in cases where inflammation worsens or doesn't resolve after initial treatment.
  • The review highlights a lack of consensus on IMT's effectiveness in infectious uveitis, pointing out its occasional use in persistent cases, while providing options for clinicians managing these complex conditions.
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This study aimed to report the diagnostic process, treatment, and follow-up of a patient with bullous exudative retinal detachment (RD) associated with an atypical variant of bilateral central serous chorioretinopathy (CSCR). A 28-year-old woman was referred to our clinic for total bullous RD in the right eye with a vision level of light perception only. She had been previously diagnosed with idiopathic uveal effusion syndrome and treated with systemic corticosteroid therapy with no response, and was referred to us for scleral window surgery.

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  • * The most common type is anterior uveitis, often linked to juvenile idiopathic arthritis, but intermediate uveitis and other forms can also occur.
  • * Close monitoring is crucial to prevent serious issues like cataracts and high intraocular pressure, with treatments including methotrexate and adalimumab, requiring a collaborative approach for effective management.
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  • The 'MHC-I-opathy' concept refers to a group of inflammatory diseases linked to the major histocompatibility complex class I, with recognized conditions including spondyloarthritis and psoriasis, all associated with specific genetic variants.
  • There is a significant challenge in understanding and treating these disorders due to differences in patient symptoms and insufficient research on the MHC-I pathway.
  • The text advocates for a collaborative approach involving diverse medical and research disciplines to standardize disease definitions, explore genetic factors, and improve therapeutic strategies, ultimately aiming to enhance patient care.
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Background: The global and precise follow-up of uveitis has become possible with the availability of dual fluorescein (FA) and indocyanine green angiography (ICGA) since the mid-1990s. Progressively, additional non-invasive imaging methods have emerged, bringing value-added precision to the imaging appraisal of uveitis, including, among others, optical coherence tomography (OCT), enhanced-depth imaging OCT (EDI-OCT) and blue light fundus autofluorescence (BAF). More recently, another complementary imaging method, OCT-angiography (OCT-A), further allowed retinal and choroidal circulation to be imaged without the need for dye injection.

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  • Treatment began with infliximab and vitreoretinal surgery, but he experienced several adverse reactions, including an infusion reaction, hepatotoxicity, and complications from other therapies.
  • After 33 months, despite being in clinical remission, he faced ongoing inflammation in his right eye and had a poor visual acuity, highlighting the need for careful monitoring and adjustments in immunomodulatory treatment for Behçet uveitis.
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Objectives: The aims of this study were to describe the clinical presentation and treatment modalities of acute retinal necrosis (ARN) and to evaluate complications and clinical outcomes according to the extent of retinal involvement at initial presentation.

Materials And Methods: The medical records of 52 patients diagnosed with ARN were reviewed and 48 were included in the study. Patients were categorized into two groups according to the extent of retinitis at presentation: retinal involvement of 1-2 quadrants (Group A) or 3-4 quadrants (Group B).

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Aims: To investigate the correlation between widefield fundus fluorescein angiography (WF-FA) and anterior chamber laser flare photometry (LFP-flare) in Behçet uveitis (BU).

Methods: Patients with BU who underwent Heidelberg WF-FA between March 2016 and March 2018 were included. Demographics, ocular findings, LFP-flare, central macular thickness were retrospectively analyzed.

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During the last decades the efficacy of biologic agents, mainly of anti-TNFs, in controlling the activity of serious manifestations of Behcet's Disease (BD) has been established. On the other hand, the clinical heterogeneity of BD has precluded the validation of a widely-accepted composite index for disease assessment and for target disease-state definitions, such as low disease activity and remission, and the testing of their implementation in clinical practice. Therefore, in contrast to other systemic rheumatic diseases, a treat-to-target strategy has not yet been developed in BD.

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