Fungal quorum sensing molecules as potential drugs in the treatment of chronic wounds and their delivery.

Introduction: Chronic non-healing wounds have emerged as a significant global healthcare challenge. Biofilm induced wound infections has been widely acknowledged. Despite the advanced understanding of biofilm formation, the existing approaches for diagnosing biofilms in wounds remain considerably suboptimal.

Efficacy of a New Alcohol-Free Organic Acid-Based Hand Sanitizer against Foodborne Pathogens.

In light of the global health crisis triggered by the COVID-19 pandemic, numerous experts have deemed the utilization of hand sanitizers imperative as a precautionary measure against the virus. Consequently, the demand for hand sanitizers has experienced a substantial surge. Since the beginning of 2020, the utilization of alcohol-free hand sanitizers has been increasingly favored due to the potential risks associated with alcohol poisoning, flammability, as well as the adverse effects on skin lipid dissolution, dehydration, and sebum reduction, which can lead to severe cases of eczema and norovirus infections.

Ciprofloxacin-Loaded Polyvinylpyrrolidone Foils for the Topical Treatment of Wound Infections with Methicillin-Resistant (MRSA).

Bacterial infections are a constant challenge in the management of acute and chronic wounds. Chronic wounds, such as diabetic foot ulcers, have increased significantly in the last few years due to the rise of an aging population. A better understanding of the infectious pathophysiological mechanisms is urgently needed along with new options for the treatment of wound infections and wound-healing disorders.

Controlled Drug Release from Nanoengineered Polysaccharides.

Polysaccharides are naturally occurring complex molecules with exceptional physicochemical properties and bioactivities. They originate from plant, animal, and microbial-based resources and processes and can be chemically modified. The biocompatibility and biodegradability of polysaccharides enable their increased use in nanoscale synthesis and engineering for drug encapsulation and release.

MEMS-Based Tactile Sensors: Materials, Processes and Applications in Robotics.

Commonly encountered problems in the manipulation of objects with robotic hands are the contact force control and the setting of approaching motion. Microelectromechanical systems (MEMS) sensors on robots offer several solutions to these problems along with new capabilities. In this review, we analyze tactile, force and/or pressure sensors produced by MEMS technologies including off-the-shelf products such as MEMS barometric sensors.

Advances in Fibrin-Based Materials in Wound Repair: A Review.

The first bioprocess that occurs in response to wounding is the deterrence of local hemorrhage. This is accomplished by platelet aggregation and initiation of the hemostasis cascade. The resulting blood clot immediately enables the cessation of bleeding and then functions as a provisional matrix for wound healing, which begins a few days after injury.

Biodegradable, Stretchable and Transparent Plastic Films from Modified Waterborne Polyurethane Dispersions.

Waterborne polyurethane dispersions can be designed to generate highly functional and environmentally friendly polymer systems. The use of water as the main dispersion medium is very advantageous for the environment and the introduction of linear and aliphatic polyols such as polyether and polyesters in the formulations can make them highly biocompatible and susceptible to biodegradation. In this study, we fabricated biodegradable, flexible and transparent plastic films by hybridizing a waterborne aliphatic polyester polyurethane (PU) suspension with polyvinylpyrrolidone (PVP) using mechanical homogenization in water.

A Review of Sustained Drug Release Studies from Nanofiber Hydrogels.

Polymer nanofibers have exceptionally high surface area. This is advantageous compared to bulk polymeric structures, as nanofibrils increase the area over which materials can be transported into and out of a system, via diffusion and active transport. On the other hand, since hydrogels possess a degree of flexibility very similar to natural tissue, due to their significant water content, hydrogels made from natural or biodegradable macromolecular systems can even be injectable into the human body.

Recent Advances in Antioxidant Polymers: From Sustainable and Natural Monomers to Synthesis and Applications.

Advances in technology have led to the production of sustainable antioxidants and natural monomers for food packaging and targeted drug delivery applications. Of particular importance is the synthesis of lignin polymers, and graft polymers, dopamine, and polydopamine, inulin, quercetin, limonene, and vitamins, due to their free radical scavenging ability, chemical potency, ideal functional groups for polymerization, abundance in the natural environment, ease of production, and activation of biological mechanisms such as the inhibition of the cellular activation of various signaling pathways, including NF-κB and MAPK. The radical oxygen species are responsible for oxidative damage and increased susceptibility to cancer, cardiovascular, degenerative musculoskeletal, and neurodegenerative conditions and diabetes; such biological mechanisms are inhibited by both synthetic and naturally occurring antioxidants.

4D printing: Perspectives for the production of sustainable plastics for agriculture.

The concept of 4D printing of phase change materials is gaining attention in the potential development of self-healing materials for tissue engineering and manufacturing applications, but there has been limited utilization of the technology in agriculture/farm-based applications. The temperature-responsiveness, magneto-responsiveness, pH-responsiveness, and osmotic pressure-responsiveness of shape-memory materials have potential applications in green/compostable plastics for agricultural applications such as food packaging and mulching films, shade nets, and greenhouse polymer covers. The application of 4D printing in augmenting the biodegradability, environmental, economic, and production benefits of polymers in agriculture is the main focus of this review.

UV-Blocking, Transparent, and Antioxidant Polycyanoacrylate Films.

Applications of cyanoacrylate monomers are generally limited to adhesives/glues (instant or superglues) and forensic sciences. They tend to polymerize rapidly into rigid structures when exposed to trace amounts of moisture. Transforming cyanoacrylate monomers into transparent polymeric films or coatings can open up several new applications, as they are biocompatible, biodegradable and have surgical uses.

Hyaluronic Acid and Controlled Release: A Review.

Hyaluronic acid (HA) also known as hyaluronan, is a natural polysaccharide-an anionic, non-sulfated glycosaminoglycan-commonly found in our bodies. It occurs in the highest concentrations in the eyes and joints. Today HA is used during certain eye surgeries and in the treatment of dry eye disease.

Bioresin-based superhydrophobic coatings with reduced bacterial adhesion.

Hypothesis: Certain biobased polymers or natural compounds can be effectively used in superhydrophobic coating formulations to reduce environmental impact of fluorinated compounds and related bioaccumulation and toxicity problems. Many environmental concerns have thus far been raised in relation to toxicity of solvents and C8 fluorine chemicals. Elimination of these important elements from non-wettable coating formulations can jeopardize non-wetting performance significantly.

Combining dietary phenolic antioxidants with polyvinylpyrrolidone: transparent biopolymer films based on p-coumaric acid for controlled release.

Polyvinylpyrrolidone (PVP) has probably been one of the most utilized pharmaceutical polymers with applications ranging from a blood plasma substitute to nanoparticle drug delivery, since its synthesis in 1939. It is a highly biocompatible, non-toxic and transparent film forming polymer. Although high solubility of PVP in aqueous environment is advantageous, it still poses several problems for some applications in which sustained targeting and release are needed or hydrophobic drug inclusion and delivery systems are to be designed.

Treatment of Coral Wounds by Combining an Antiseptic Bilayer Film and an Injectable Antioxidant Biopolymer.

Coral reefs are vital for the marine ecosystem and their potential disappearance can have unequivocal consequences on our environment. Aside from pollution-related threats (changes in water temperature, plastics, and acidity), corals can be injured by diseases, predators, humans and other invasive species. Diseases play an important role in this decline, but so far very few mitigation strategies have been proposed and developed to control this threat.

Evaluation of Drug Delivery and Efficacy of Ciprofloxacin-Loaded Povidone Foils and Nanofiber Mats in a Wound-Infection Model Based on Ex Vivo Human Skin.

Topical treatment of wound infections is often a challenge due to limited drug availability at the site of infection. Topical drug delivery is an attractive option for reducing systemic side effects, provided that a more selective and sustained local drug delivery is achieved. In this study, a poorly water-soluble antibiotic, ciprofloxacin, was loaded on polyvinylpyrrolidone (PVP)-based foils and nanofiber mats using acetic acid as a solubilizer.

Environmentally benign non-wettable textile treatments: A review of recent state-of-the-art.

Among superhydrophobic materials, non-wettable textiles are probably the ones that come in contact or interact with the human body most frequently. Hence, textile treatments for water or oil repellency should be non-toxic, biocompatible, and comply with stringent health standards. Moreover, considering the volume of the worldwide textile industry, these treatments should be scalable, sustainable, and eco-friendly.

Poly(furfuryl alcohol)-Polycaprolactone Blends.

Poly(furfuryl alcohol) (PFA) is a bioresin synthesized from furfuryl alcohol (FA) that is derived from renewable saccharide-rich biomass. In this study, we compounded this bioresin with polycaprolactone (PCL) for the first time, introducing new functional polymer blends. Although PCL is biodegradable, its production relies on petroleum precursors such as cyclohexanone oils.

Stacked-Cup Carbon Nanotube Flexible Paper Based on Soy Lecithin and Natural Rubber.

Stacked-cup carbon nanotubes (SCCNTs) are generally referred to as carbon nanofibers (CNFs). SCCNTs are much less expensive to fabricate and are regarded as good polymer modifiers suitable for large-scale production. Flexible, SCCNT-based soy lecithin biocomposites were fabricated using liquid natural rubber latex as binder.

Fabrication of Visible Light-Induced Antibacterial and Self-Cleaning Cotton Fabrics Using Manganese Doped TiO Nanoparticles.

Ordinary textiles are very often malodorous and the origin of cross-infection. Their microclimate, consisting of moisture, contaminants, and sweat, provides favorable conditions for microbial growth. Therefore, simple approaches of surface modification using functional materials are widely adopted to introduce antibacterial properties.

Highly Transparent Polyethylcyanoacrylates from Approved Eco-Friendly Fragrance Materials Demonstrating Excellent Fog-Harvesting and Anti-Wear Properties.

Superglue monomers belong to a family of cyanoacrylates that are known for their very rapid polymerization upon contact with moist surfaces. Their biodegradation and low toxicity make them attractive as medical and veterinary adhesives. Although the fast-acting polymerization characteristics have been successfully utilized to design nanoscale polymeric particles that can carry drugs or other inorganic nanoparticles, it constitutes a significant drawback if one desires to produce other forms of functional biodegradable acrylics, such as coatings, sheets, or nanocomposites.

Antimicrobial, antioxidant, and waterproof RTV silicone-ethyl cellulose composites containing clove essential oil.

Ethyl cellulose (EC)/polydimethylsiloxane (PDMS) composite films were prepared at various concentrations of PDMS in the films (0, 5, 10, 15, and 20 wt.%). Morphological and chemical analysis by EDX-SEM and ATR-FTIR showed that EC-rich matrices and PDMS-rich particles were formed, with the two polymers interacting through Hbonds.

Carbon Nanofiber versus Graphene-Based Stretchable Capacitive Touch Sensors for Artificial Electronic Skin.

Stretchable capacitive devices are instrumental for new-generation multifunctional haptic technologies particularly suited for soft robotics and electronic skin applications. A majority of elongating soft electronics still rely on silicone for building devices or sensors by multiple-step replication. In this study, fabrication of a reliable elongating parallel-plate capacitive touch sensor, using nitrile rubber gloves as templates, is demonstrated.

Interfacing superhydrophobic silica nanoparticle films with graphene and thermoplastic polyurethane for wear/abrasion resistance.

Hypothesis: Nanoparticle films are one of the most suitable platforms for obtaining sub-micrometer and nanometer dual-scale surface texture required for liquid repellency. The assembly of superhydrophobic nanoparticles into conformal and strongly adherent films having abrasion-induced wear resistance still poses a significant challenge. Various techniques have been developed over the years to render nanoparticle films with good liquid repellent properties and transparency.