The HR antagonist, JNJ-7777120 treatments ameliorate mild traumatic brain injury by reducing oxidative damage, inflammatory and apoptotic responses through blockage of the ERK1/2/NF-κB pathway in a rat model.

Growing evidence reveals that microglia activation and neuroinflammatory responses trigger cell loss in the brain. Histamine is a critical neurotransmitter and promotes inflammatory responses; thus, the histaminergic system is a potential target for treating neurodegenerative processes. JNJ-7777120, a histamine H4 receptor (HR) antagonist, has been shown to alleviate inflammation, brain damage, and behavioral deficits effectively, but there is no report on its role in brain trauma.

The Importance of Spinopelvic Parameters in Recurrent Lumbar Disk Herniation.

Study Design: Retrospective clinical study.

Objectives: We aimed to investigate preoperative spinopelvic mismatch as a risk factor for recurrent lumbar disk herniation (RLDH) in patients undergoing lumbar disk herniation (LDH) surgery.

Summary Of Background Data: Spinopelvic parameters have been associated with lumbar degenerative diseases, particularly LDH.

A new posterior stabilization technique in pediatric subaxial cervical vertebrae: Stabilization of spinous processes with the microplate/screw system: A radiological anatomy study.

Background: There are limited options for posterior stabilization techniques in cases of cervical subaxial instability in children. We designed this study to investigate whether the spinous process (SP) stabilization, which was previously used in adults, can also be used in children.

Methods: Children aged 4-12 years who were admitted to our hospital between 2012 and 2020 and underwent 3D cervical computed tomography (CT) were retrospectively screened.

The calcimimetic R-568 attenuates subarachnoid hemorrhage-induced vasospasm through PI3K/Akt/eNOS signaling pathway in the rat model.

Cerebral vasospasm (CVS) causes mortality and morbidity in patients after subarachnoid hemorrhage (SAH). The mechanism and adequate treatment of CVS are still elusive. R-568 is a calcimimetic agent known to exert a vasodilating effect.

Does the Position of the Polyaxial Screw Head in Patients With L5-S1 Stabilization Lead to an Increased Difficulty in L5 Transforaminal Nerve Injection? A Three-Dimensional Computerized Tomography Study.

Background Challenges may be encountered if transforaminal nerve injection (TFNI) is required in patients who have undergone posterior transpedicular stabilization (PTS) surgery to the L5-S1 level. In this study, we investigated the contributory factors that lead to these challenges. Methods We selected 125 patients who underwent PTS surgery involving the L5-S1 segment, between 18 to 70 years of age to be included in the study.

Suitability of the Subaxial Cervical Laminae for Laminar Screws in the Pediatric Population: A Radiologic Anatomical Study.

Introduction: The laminar screw method was popularized during recent years. Since no data exist in the literature on its suitability for subaxial levels in the pediatric population, a radiologic anatomical study was planned to evaluate the suitability of the laminae for laminar screws in children.

Methods: The laminar thicknesses from C3 to C7 were measured in axial sections in 120 pediatric patients using computed tomography.

Immediate versus delayed primary repair of the sciatic nerve in a nerve transaction model in rats.

Background: The debate continues concerning surgical timing in a peripheral nerve injury. This study aims to evaluate the result of immediate versus delayed primary (after seven days) repair of peripheral nerve injury.

Methods: In this study, Wistar rats were divided into four groups as follows: The nerve was sharply transected in Group 1, 2 and 4.

Television Tip-Over Related Head Injuries: A Particular Type of Child Neglect.

Aim: To identify, report, and raise awareness of the risk factors for television (TV) tip-over.

Material And Methods: In total, 86 children who were brought to the emergency service and hospitalized at the neurosurgery clinic because of TV tip-over-related head trauma between August 2011 and August 2016 were included in the study.

Results: The 86 patients consisted of 47 males and 39 females.

Use and modifications of cervical and upper thoracic laminar screws in posterior stabilization.

Aim: Laminar screw technique is used to stabilize C2 and other levels when other techniques cannot be performed.

Material And Methods: The patients underwent laminar screws at cervical and upper thoracic levels in our clinic during 5 yearswere evaluated retrospectively.

Results: In 25 patients, 6 to 82 years old,total 54 laminar screws were used.

Metastatic Gallbladder Carcinoma in Meningioma: A Case Report.

Metastases from tumors to systemic cancers are rare. The most common intracranial recipient tumor is meningioma. Metastasis from gallbladder cancer has been previously reported from only one patient during autopsy.

Empty Bladed PEEK Cage for Interbody Fusion after Anterior Cervical Discectomy.

Aim: Cervical disc herniation (CDH) can be treated using different anterior and posterior methods. Anterior cervical discectomy and fusion (ACDF) is currently gold standard and provides bony fusion and good clinical outcome. Recently many studies reported good clinical and radiological outcomes in cases who underwent anterior cervical discectomy (ACD) and reconstruction with empty cage.

The Role of Wrist Magnetic Resonance Imaging in the Differential Diagnosis of the Carpal Tunnel Syndrome.

Aim: The carpal tunnel syndrome (CTS) is the commonest compressive neuropathy. Electromyography (EMG) is accepted as gold standard in diagnosis of CTS. However, pathologies and variations that are associated with a various findings may lead to failure.

Bilateral Lhermitte-Duclos disease.

Lhermitte-Duclos disease (LDD) is a pathologic entity with progrediating, diffuse hypertrophy chiefly of the stratum granulosum of the cerebellum. Typically LDD is a unilateral lesion of the cerebellum or in vermis. Here we report a case of LDD with bilateral lesions of cerebellar hemispheres managed surgically.

Sudden paraplegia following epidural lipomatosis and thoracal compression fracture after long-term steroid therapy: a case report.

Sudden paraplegia secondary to the posterior spinal epidural compression and vertebral compression fracture as a complication in corticosteroid treatment is extremely rare. The authors presented a case 49-year-old man with chronic relapsing attack of Still's disease. After the identification of pathology, the surgical evacuation of lipid tissue and pedicle-based instrumentation showed therapeutic success.

Frontal bone and epidural tuberculosis.

Cranial bone and epidural tuberculosis is rare manifestation extrapulmonary tuberculosis. The incidence of tuberculosis of calvaria is on the rise in developing countries because of malnutrition, poor socioeconomic conditions, and immunodeficiency. We present the clinical features, radiology, histopathology, and surgical findings of a case of tuberculosis of the frontal bone with epidural extension.

A case of McCune-Albright syndrome associated with Gs alpha mutation in the bone tissue.

The syndrome of McCune-Albright syndrome (MAS) is clasically defined as a triad presentation with the findings of polyostotic fibrous dysplasia, café-au-lait spots, and sexual precocity. However, not all patients present with complete symptoms. A 52-year-old man was diagnosed as having a variant of McCune-Albright syndrome with the following findings: polyostotic fibrous dysplasia, acromegaly due to pituitary tumor and subclinical hyperthyroidism due to toxic multinodular goiter.