Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study.

Background: Reduced antioxidant defenses may reflect a poor protective response against oxidative stress and this may be implicated in progression of gestational diabetes mellitus (GDM). Oxidative stress induced by hyperglycemia plays a major role in micro and macrovascular complications, which imply endothelial dysfunction.

Objective: Our aim in this study was to investigate the association between GDM and oxidative stress markers measured in plasma, with regard to revealing changes to total antioxidant capacity (TAC) and total oxidant status (TOS) among mothers showing impairments in oral glucose tolerance tests (OGTTs).

The relationship between adiponectin levels and epicardial adipose tissue thickness in non-obese children with asthma.

Background: There is an association between adiponectin (APN) and asthma. However, the mechanisms underlying this association is unclear. APN is a predominantly anti-inflammatory protein with possible signalling activity in the lung that can be secreted by Epicardial Adipose Tissue (EAT).

Surgery vs medical treatment in the management of PFAPA syndrome: a comparative trial.

Background: Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome is a common disorder in children but there is little or no consensus on its optimal diagnosis and management.

Objectives: To compare the outcome of different management approaches - medical therapy or tonsillectomy.

Methods: The medical records of children diagnosed with PFAPA between 2008 and 2013 were retrospectively reviewed according to the modified Thomas test criteria.

Evaluation of the effects of serum iron levels on lacrimal gland secretion.

In our study we aimed to demonstrate the relationship between the serum iron levels, and tears quality and quantity in term newborns. This study was conducted at a single institution between March 2013 and May 2013. A total of 46 newborns were prospectively enrolled.

Relationship between procalcitonin levels and presence of vesicoureteral reflux during first febrile urinary tract infection in children.

Objective: To investigate the association between the procalcitonin (PCT) level during the first febrile urinary tract infection (UTI) in children and the presence of vesicoureteral reflux (VUR). VUR-associated UTI is among the primary causes of chronic renal failure in Turkey.

Methods: From March 2008 to November 2009, patients admitted with their first febrile UTI were included in the present prospective hospital-based study.

Does cord blood bilirubin level help the physician in the decision of early postnatal discharge?

Objective: Early postnatal discharge of newborns leads to the risk of readmission to the hospital, mostly for neonatal hyperbilirubinemia. Increasing the length of hospital stay is not an acceptable solution for medical, social and economic constraints. Hence, predicting the high risk neonates for subsequent hyperbilirubinemia is required.

The efficacy of nebulized salbutamol, hypertonic saline and salbutamol/hypertonic saline combination in moderate bronchiolitis.

Background: The mainstay of treatment in bronchiolitis includes oxygenation, aspiration of secretions from the respiratory tract and maintenance of hydration. The first choice medical agent in clinical practice is nebulized bronchodilators, although their place in treatment is controversial.

Objectives: We investigated the therapeutic benefit of nebulized hypertonic (3%) saline (HS), by comparing four different nebulized regimens in the treatment of bronchiolitis in the emergency department.

Antimicrobial resistance patterns of uropathogens among children in Istanbul, Turkey.

Urinary tract infections are a common cause of end-stage renal disease in Turkey. This prospective study investigated the antibiotic resistance patterns of uropathogens in order to recommend appropriate therapeutic protocols for children with urinary tract infections in Istanbul, Turkey. Between October 2007 and October 2008, children presenting with a first episode of urinary tract infection to a pediatric outpatient clinic were enrolled in the study.

Alpha1-acid glycoprotein for the early diagnosis of neonatal sepsis.

Objective: We aimed to evaluate the diagnostic value of C-reactive protein (CRP) and alpha1-acid glycoprotein (alpha1AG) in the early diagnosis of neonatal sepsis.

Design: The study was prospectively conducted among newborns hospitalized for 'rule out sepsis' to neonatal intensive care unit (NICU).

Setting And Subjects: A total of 97 children [16 with confirmed sepsis (Group I), 34 with clinical sepsis (Group II), and 47 in control group (Group III)] were enrolled in the study.

Predicting neonatal sepsis in ventilated neonates.

Objective: To show the value of serial endotracheal aspirate culture in predicting organisms causing sepsis in ventilated neonates.

Methods: We studied 100 newborns in Zeynep Kamil Maternity and Children's Training and Research Hospital Neonatal Intensive Care Unit. Endotracheal aspirate and blood cultures were taken first on the third day and then once a week till extubation.

Efficacy of salbutamol and ipratropium bromide in the management of acute bronchiolitis--a clinical trial.

Background: A wide range of drugs are commonly used to treat bronchiolitis, but evidence of their effectiveness is limited.

Objectives: To investigate the efficacy of ipratropium bromide and salbutamol in the treatment of patients with moderate-severe bronchiolitis.

Methods: Sixty-nine infants with moderate-severe bronchiolitis hospitalized at their first episode of wheezing or crepitations in the chest were enrolled in a prospective, double-blind, placebo-controlled trial.

Glucose-6-phosphate dehydrogenase deficiency in neonatal indirect hyperbilirubinemia.

The aim of this article is to investigate the prevalence of Glucose-6-phosphate dehydrogenase (G6PD) deficiency in neonatal hyperbilirubinemia and to compare the clinical presentation and course of G6PD-deficient and normal patients. This study included a total of 624 term neonates with indirect hyperbilirubinemia from March 2001 to September 2004. Birth weight, sex, weight at admission, serum bilirubin at admission, maximum bilirubin, phototherapy duration, duration of hospitalization and the need for exchange transfusion were recorded.