Publications by authors named "Ilka Thomsen"
EGFR stimulation enables IL-6 trans-signalling via iRhom2-dependent ADAM17 activation in mammary epithelial cells.
Biochim Biophys Acta Mol Cell Res
October 2023
The cytokine interleukin-6 (IL-6) has considerable pro-inflammatory properties and is a driver of many physiological and pathophysiological processes. Cellular responses to IL-6 are mediated by membrane-bound or soluble forms of the IL-6 receptor (IL-6R) complexed with the signal-transducing subunit gp130. While expression of the membrane-bound IL-6R is restricted to selected cell types, soluble IL-6R (sIL-6R) enables gp130 engagement on all cells, a process termed IL-6 trans-signalling and considered to be pro-inflammatory.
View Article and Find Full Text PDFMetastasis is the major cause of death in cancer patients. Circulating tumor cells need to migrate through the endothelial layer of blood vessels to escape the hostile circulation and establish metastases at distant organ sites. Here, we identified the membrane-bound metalloprotease ADAM17 on endothelial cells as a key driver of metastasis.
View Article and Find Full Text PDFArticle Synopsis
- Scientists studied how a special protein called gp130 affects liver cells and their immune response to infections.
- They created mice with specific liver cells reacting to gp130 to see how these cells work differently.
- The research found that when liver cells called hepatocytes were activated, they helped the mice fight infections better, but other liver cells didn't show major changes.