Publications by authors named "Iliya V Byzov"
A series of new composite materials based on FeO magnetic nanoparticles coated with SiO (or aminated SiO) were synthesized. It has been shown that the use of -(phosphonomethyl)iminodiacetic acid (PMIDA) to stabilize nanoparticles before silanization ensures the increased content of a SiO phase in the FeO@SiO nanocomposites (NCs) in comparison with materials obtained under similar conditions, but without PMIDA. It has been demonstrated for the first time that the presence of PMIDA on the surface of NCs increases the level of Dox loading due to specific binding, while surface modification with 3-aminopropylsilane, on the contrary, significantly reduces the sorption capacity of materials.
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- Researchers created innovative organosilicon MNPs modified with pHLIP and PEG, showing enhanced specificity and low cytotoxicity in vitro, particularly at acidic pH levels.
- The study revealed that these pHLIP-modified MNPs accumulated significantly more in tumors compared to standard PEGylated MNPs in mouse models, indicating their potential for better cancer imaging.
Article Synopsis
- * It was found that the best modification conditions involved a reaction at 40 °C with an equimolar amount of PMIDA for 3.5 hours, resulting in good colloidal stability and high magnetic properties of the MNPs.
- * The PMIDA-modified MNPs showed superior performance with relaxivity values of 341 and 102 mmol s, and were successfully tested as a T1 contrast agent for liver imaging in vivo, indicating their potential medical application.
Article Synopsis
- Liver fluke infection can severely damage the liver but is often overlooked due to unclear symptoms; nanoparticle-enhanced MRI could help detect related liver lesions effectively.
- Researchers modified iron oxide nanoparticles using 3-aminopropylsilane (APS) and analyzed their properties through various techniques to confirm structural integrity and enhance their magnetic capabilities for imaging.
- The study found that these APS-modified nanoparticles can be used as a contrast agent in MRI, showing promising results for diagnosing liver damage caused by liver flukes with minimal toxicity to cells.