Reactivation of tuberculosis in patient treated with the antifibrotic drug nintedanib.

The novel antifibrotic drugs for idiopathic pulmonary fibrosis give us an opportunity for change the course of the disease. Their usages are expected to rise with the widening of their indications. We report a case of a patient who complains of fatigue breathlessness on exertion, dry cough, and fever up to 38°C while on the antifibrotic drug nintedanib treatment.

Stability of Frequent Exacerbator Phenotype in Patients with Chronic Obstructive Pulmonary Disease.

Background: At present, there is little information in Bulgaria regarding the rate and stability of frequent-exacerbation phenotype in COPD patients.

Aim: To study the rate and stability of frequent-exacerbation phenotype in COPD patients.

Materials And Methods: We followed up 465 COPD patients for exacerbations over a 3-year period.

Impact of Air Pollution and Outdoor Temperature on the Rate of Chronic Obstructive Pulmonary Disease Exacerbations.

Background: Environmental pollution can be one of the main risk factors for acute exacerbations of chronic obstructive pulmonary disease (COPD).

Aim: To study the relationship between air pollution, outdoor temperature and exacerbations of COPD.

Materials And Methods: COPD patients (n=1432) were followed up for one year.