Publications by authors named "Ilin V Joshi"
Article Synopsis
- - The airway smooth muscle (ASM) cell's function in contraction and remodeling relies on changes in its cytoskeleton, shifting between a relaxed "fluid-like" state and a contractile "solid-like" state based on protein interactions.
- - The review explores the roles of various cytoskeletal components, such as actin and myosin, as well as factors that influence their behavior and how these interactions relate to the airway's extracellular matrix and the physical mechanics of airway movement.
- - The findings highlight new insights into the mechanisms of ASM cell activity, which could inform approaches to understanding and treating asthma-related airway obstruction.
Regulators of G protein signaling (RGS) proteins constrain G protein-coupled receptor (GPCR)-mediated and other responses throughout the body primarily, but not exclusively, through their GTPase-activating protein activity. Asthma is a highly prevalent condition characterized by airway hyper-responsiveness (AHR) to environmental stimuli resulting in part from amplified GPCR-mediated airway smooth muscle contraction. Rgs2 or Rgs5 gene deletion in mice enhances AHR and airway smooth muscle contraction, whereas RGS4 KO mice unexpectedly have decreased AHR because of increased production of the bronchodilator prostaglandin E2 (PGE2) by lung epithelial cells.
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