Extensively-drug resistant bacteremia in neonates: effective treatment with the combination of colistin and ampicillin/sulbactam.

has evolved as a major pathogen of outbreaks in the healthcare setting with increased morbidity and mortality. In neonates, treatment can be quite challenging due to the resistance profile of as well as limited data on pharmakokinetics and pharmakodynamics of antibiotics in this age group. We present an outbreak of eight cases of extensively-drug resistant (XDR) bacteremias successfully managed with the combination of colistin with high dose ampicillin/sulbactam.