Publications by authors named "Iliana Ouzounov"
Article Synopsis
- When telomeres get critically short, they trigger a cellular response to DNA damage by recruiting repair factors to chromosome ends.
- Researchers used a technique called proteomic isolation of chromatin fragments to study changes in chromatin when telomere dysfunction occurs due to loss of TRF2.
- The study identified the polycomb group protein Ring1b as being essential for repairing damaged telomeric chromatin, with findings showing that lower levels of Ring1b decrease the cell's ability to effectively repair damaged telomeres.
Mammalian telomeres repress DNA-damage activation at natural chromosome ends by recruiting specific inhibitors of the DNA-damage machinery that form a protective complex termed shelterin. Within this complex, TRF2 (also known as TERF2) has a crucial role in end protection through the suppression of ATM activation and the formation of end-to-end chromosome fusions. Here we address the molecular properties of TRF2 that are both necessary and sufficient to protect chromosome ends in mouse embryonic fibroblasts.
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