Publications by authors named "Ilia S Avrusin"
Hemophagocytic syndrome is a key point in the pathogenesis of severe forms of multisystem inflammatory syndrome associated with COVID-19 in children (MIS-C). The factors associated with hemophagocytosis in patients with MIS-C were assessed in the present study of 94 boys and 64 girls ranging in age from 4 months to 17 years, each of whose HScore was calculated. In accordance with a previous analysis, patients with HScore ≤ 91 ( = 79) and HScore > 91 ( = 79) were compared.
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- The study focuses on Multisystem Inflammatory Syndrome in Children (MIS-C) related to COVID-19, a severe condition often requiring ICU care.
- It analyzed 166 patients, finding that older children and those exhibiting specific symptoms like rashes, swelling, and respiratory issues were more likely to experience severe MIS-C.
- Key predictors for severe cases included significant increases in certain blood markers (CRP, troponin, D-dimer) and physical signs such as hepatomegaly and splenomegaly, which could help identify at-risk patients early on.
Article Synopsis
- This study investigates cases of vasculitis in children linked to COVID-19, highlighting a limited but concerning phenomenon.
- Four pediatric cases showed diverse systemic involvement, primarily affecting the skin; while all patients presented with high inflammatory markers, none fully met criteria for multisystem inflammatory syndrome.
- Treatment included systemic glucocorticosteroids, with additional therapies like DMARDs and biologics, underscoring the potential severity of COVID-19-related vasculitis and the need for more comprehensive research.
Objectives: Heart involvement in multisystem inflammatory syndrome associated with COVID-19 in children (MIS-C) is a new challenging problem, requiring fast and reliable diagnostics and appropriate treatment. The aim of this study is to describe heart involvement in patients with MIS-C.
Study Design: In this retrospective, multicenter cohort study, data of 122 patients were included.
Diagnostic between multisystem inflammatory syndrome associated with COVID-19 in children (MIS-C) and Kawasaki disease (KD) can make difficulties due to many similarities. Our study aimed to create a Kawasaki/MIS-C differentiation score (KMDscore) allowing discrimination of MIS-C and KD. The retrospective multicenter cohort study included clinical, laboratory, and instrumental information about MIS-C ( = 72) and KD ( = 147).
View Article and Find Full Text PDFTo describe the clinical characteristics of hip involvement in juvenile idiopathic arthritis (JIA) from arthritis to hip osteoarthritis (HOA) and total hip arthroplasty (THA). Seven hundred fifty-three patients aged 2-17 years with JIA were included in the study. The comparison analysis was performed between the following subgroups: (i) JIA without hip involvement ( = 600; 79.
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