Publications by authors named "Ilia D Mantle"
Article Synopsis
- The mammary gland's epithelial components originate from stem cells capable of self-renewal and differentiation, which may also be involved in cancer transformation.
- Research utilizing in vitro techniques and animal models has revealed that hedgehog signaling and the polycomb gene Bmi-1 are crucial in regulating the self-renewal of both normal and malignant human mammary stem cells.
- Enhanced hedgehog signaling promotes the growth of mammosphere-initiating cells, while inhibiting this pathway leads to decreased growth, suggesting its significant role in both healthy and cancerous mammary stem cell functions.
