Synopsis of recent research by authors named "Ilhan Isikdag"
Ilhan Isikdag's research primarily focuses on the synthesis and evaluation of various benzimidazole and bisbenzimidazole derivatives for their potential anticancer and antimicrobial activities, highlighting their role as inhibitors of DNA topoisomerases and their antimicrobial properties against different bacterial strains.
Recent studies have shown that despite the promising structural characteristics of some synthesized compounds, many displayed weak antimicrobial activity and variable efficacy against cancer cell lines, suggesting a need for further optimization.
Additionally, Isikdag's investigations into the mutagenicity of select bisbenzimidazole derivatives revealed significant mutagenic effects in specific bacterial strains, raising concerns about their safety as therapeutic agents, while also contributing to the understanding of structure-activity relationships in drug development.
