Publications by authors named "Ilenia De Leo"
Lung cancer is the leading cause of cancer-related death worldwide. Non-coding RNAs are emerging as critical players for the onset and progression of cancer. Analyses of three different datasets revealed that the lncRNA JPX was overexpressed in adenocarcinoma tissues in comparison to normal lungs, as expected for an oncogene.
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- Small non-coding RNAs (ncRNAs), especially miRNAs, are crucial for many biological processes related to both health and disease, and they can move between different cell compartments.
- This study discovered piRNAs (a type of ncRNA) in mitochondria for the first time, highlighting a significant link between mitochondria and piRNA pathways across various mouse tissues.
- The research also identified both shared and unique mitochondrial miRNAs (mitomiRs) in different tissues, which may be tied to the fundamental or context-specific functions of mitochondria, providing valuable insights for future studies on ncRNA regulation and mitochondrial roles.
Given the increasing interest in bioactive dietary components that can modulate gene expression enhancing human health, three metabolites isolated from hemp seeds-cannabidiolic acid, --caffeoyltyramine, and cannabisin B-were examined for their ability to change the expression levels of microRNAs in human neural cells. To this end, cultured SH-SY5Y cells were treated with the three compounds and their microRNA content was characterized by next-generation small RNA sequencing. As a result, 31 microRNAs underwent major expression changes, being at least doubled or halved by the treatments.
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