SERCA-1 conformational change exerted by the Ca-channel blocker diltiazem affects mammalian skeletal muscle function.

In skeletal muscle (SM), inward Ca-currents have no apparent role in excitation-contraction coupling (e-c coupling), however the Ca-channel blocker can affect twitch and tetanic muscle in mammalian SM. Experiments were conducted to study how diltiazem (DLZ) facilitates e-c coupling and inhibits contraction. 1) In complete Extensor Digitorum Longus (EDL) muscle and single intact fibres, 0.