Publications by authors named "Ilayda Ozsan McMillan"
Article Synopsis
- TREM2 is an important receptor in the immune system that plays roles in inflammation, cell survival, and neuroprotection, with variations linked to Alzheimer's disease.
- The study investigates how TREM2 interacts with heparan sulfate (HS) on microglial cells, revealing that TREM2 forms complexes with HS and requires specific structural features of HS for effective binding.
- Findings suggest that this interaction is crucial for TREM2's role in microglial function, particularly in facilitating the uptake of ApoE3, potentially offering targets for interventions in Alzheimer's disease.
Alzheimer's disease (AD) is a debilitating neurodegenerative disease characterized by the accumulation of extracellular amyloid-β peptides (Aβ) within the cerebral parenchyma and vasculature, which is known as cerebral amyloid angiopathy (CAA). This study utilized confocal imaging to investigate heparan sulfate (HS) expression within the cerebrovasculature and its associations with Aβ, gender, and ApoE4 genotype in AD. Our investigation revealed elevated levels of HS in the cerebrovasculature of AD patients with severe CAA.
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- * Heparan sulfate (HS), a polysaccharide, interacts with Aβ in the brain, promoting its aggregation, internalization, and causing toxic effects; studies in mice show HS's role in regulating Aβ clearance and neuroinflammation.
- * This review discusses recent findings on how abnormal HS expression affects Aβ metabolism and AD progression, emphasizing the need for further research on HS's structure and function in relation to the disease.