Publications by authors named "Ilaria Vigorito"
Aneuploidy results in a stoichiometric imbalance of protein complexes that jeopardizes cellular fitness. Aneuploid cells thus need to compensate for the imbalanced DNA levels by regulating their RNA and protein levels, but the underlying molecular mechanisms remain unknown. In this study, we dissected multiple diploid versus aneuploid cell models.
View Article and Find Full Text PDFVascular calcification (VC) is an age-related complication characterised by calcium-phosphate deposition in the arterial wall driven by the osteogenic transformation of vascular smooth muscle cells (VSMCs). The JAK-STAT pathway is an emerging target in inflammation. Considering the relationship between VC and inflammation, we investigated the role of JAK-STAT signalling during VSMC calcification.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the role of extracellular amyloid fibrils in the tumor microenvironment and their connection to cancer progression and drug resistance through the activation of the YAP transcriptional co-activator.
- It identifies the glycocalyx protein Agrin as a key player that binds to amyloid fibrils, initiating a mechano-signaling process observed in melanoma and pancreatic cancer cells.
- The research sheds light on how amyloid fibrils enhance cancer cell migration and invasion, paving the way for potential new strategies to control YAP activation and its negative impact on cancer growth.