Publications by authors named "Ilaria Trave"

Imiquimod 5% cream is an approved treatment for actinic keratoses, superficial basal cell carcinomas, and anogenital warts. Severe systemic side effects associated with imiquimod 5% cream are rare, although a few cases of erythema multiforme and Stevens-Johnson syndrome have been described. We present a case of Stevens-Johnson syndrome associated with topical treatment with imiquimod of two superficial basal cell carcinomas.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the relationship between Demodex mite proliferation and rosacea flare-ups, focusing on both facial and scalp areas in patients with papulopustular rosacea.* -
  • A standardized skin biopsy was performed to measure Demodex counts, revealing a significantly higher frequency of Demodex mites on the scalp and face in rosacea patients compared to controls.* -
  • The primary species detected was Demodex folliculorum, suggesting that the scalp may serve as a reservoir for these mites, potentially complicating treatment effectiveness.*
View Article and Find Full Text PDF
Article Synopsis
  • - The study investigates the role of Demodex mites in rosacea, comparing the effectiveness of PCR testing to traditional microscopic examination for identifying infestations.
  • - Results showed that patients with rosacea had significantly higher rates of Demodex detection compared to controls, with PCR being much more sensitive than microscopy for detection.
  • - The findings suggest a correlation between the presence of Demodex mites and the severity of facial symptoms, indicating that the scalp may also harbor these mites; additional research on non-invasive sampling methods like PCR is recommended.
View Article and Find Full Text PDF

Allergic contact dermatitis (ACD) is a common inflammatory skin disease caused by delayed hypersensitivity to chemical and biotic contact allergens. ACD significantly affects the patients' quality of life negatively impacting both occupational and non-occupational settings. Patch testing is the gold standard diagnostic in vivo test to precise the ACD etiology and to correctly perform prevention.

View Article and Find Full Text PDF
Article Synopsis
  • The study examined lesser-known symptoms of rosacea and demodicosis, such as facial follicular scales, dandruff, scalp itching, and eye issues in patients with various severities of papulopustular rosacea (PPR).
  • Out of 60 patients, significant percentages showed these symptoms, with follicular scales being more common in mild to moderate cases and scalp itching most prevalent in moderate rosacea.
  • The research found notable differences between Demodex-positive (D+) and Demodex-negative (D-) patients, suggesting that these symptoms may indicate more severe forms of rosacea or demodicosis, and should be actively looked for in all PPR patients.
View Article and Find Full Text PDF

Background: Conventional photodynamic therapy (c-PDT) is an effective treatment for actinic keratoses (AKs) and nonmelanoma skin cancer which exploits the photosensitizing properties of methyl aminolaevulinate (MAL). Daylight photodynamic therapy (DL-PDT) is an alternative to c-PDT which does not require the application of MAL in occlusion and that is better tolerated by patients. The impact of occlusion on the efficacy of DL-PD has not been investigated by previous studies.

View Article and Find Full Text PDF
Article Synopsis
  • Acne fulminans (AF) is a severe type of acne characterized by painful, bleeding pustules and ulcerations, which may involve systemic symptoms and lab abnormalities.* -
  • A review of 98 relevant articles revealed that different variants of AF present unique clinical features, with androgen-induced AF showing more nodules and cysts, while "miscellaneous AF" tends to have more ulcerations and erosions.* -
  • Understanding the different presentations of AF is important for developing personalized treatment plans, leading to a proposed classification based on associated factors.*
View Article and Find Full Text PDF
Article Synopsis
  • A study investigated the effects of dupilumab exposure during pregnancy in women with atopic dermatitis, focusing on safety and outcomes for both mothers and infants.
  • Researchers analyzed data from 19 hospitals in Italy, identifying 29 pregnant patients who used dupilumab, with the majority reporting unplanned pregnancies and stopping the medication when they learned of their pregnancy.
  • The findings indicated no significant risks associated with dupilumab for adverse pregnancy or neonatal outcomes, suggesting safety for its use in early pregnancy, but further monitoring is recommended for continued use throughout pregnancy.
View Article and Find Full Text PDF

Introduction: During the COVID-19 pandemic, personal protective equipment, particularly face masks, became an essential requirement to engage in various activities. Several articles reported an increase of recurrences of dermatologic facial diseases (ie, acne, rosacea) related to mask use.

Objectives: To evaluate the number of recurrences of rosacea related to face mask use.

View Article and Find Full Text PDF

Atopic dermatitis and psoriasis are traditionally considered diseases that cannot coexist, since they are described as the result of the activation of opposing inflammatory pathways. However, this belief has been debunked, and numerous cases of psoriasis induced by dupilumab, a biologic treatment for atopic dermatitis, have been reported. We report three cases of dupilumab-induced psoriasis and we present a literature review including cases of "de novo" psoriasis and of the relapse of psoriasis that occurred during treatment with dupilumab.

View Article and Find Full Text PDF

Anogenital warts (AWs) represent a therapeutic challenge, especially in infants, due to sensitive skin and frequent disease recurrence. Though the initial wait-and-see approach is often adopted in asymptomatic immunocompetent children, with spontaneous clearing in almost 90% of cases within two years, persistent or symptomatic lesions can be reasonably treated. However, few studies have been conducted on children.

View Article and Find Full Text PDF

Introduction: Topical ivermectin is an anti-inflammatory and anti-Demodex drug for papulopustular rosacea. Rosacea is a relapsing disease and the time between recurrences should be considered alongside efficacy.

Objectives: The aims of this study were to assess the time of first relapse and relapse rates of Demodex mite infestation and papulopustular rosacea.

View Article and Find Full Text PDF