Investigating chemical diversity: -propargylphenols as key compounds in the divergent synthesis of 2-substituted benzofurans and chromenes.

In this study, we explored and optimized a MW-enhanced divergent approach for the synthesis of 2-substituted benzofurans and chromenes, starting from seventeen substituted -propargylphenols characterized by a monoaryl substitution on the propargylic sp carbon. Firstly, we developed a robust platform for the preparation of a library of -propargylphenols. Under basic conditions, -propargylphenols reacted regioselectively to yield benzofurans in yields ranging from 43% to 100%.