Publications by authors named "Ilaria Linda Dellarole"
Most neurodegenerative diseases lack definitive diagnostic tests, and the identification of easily accessible and reliable biomarkers remains a critical unmet need. Since tau protein is highly expressed in skin of tauopathies patients, we aimed to exploit the ultrasensitive seeding activity assay (SAA) to assess tau seeding activity in skin of patients with tauopathies. In this multicentric, case-control study, patients with tauopathies and synucleinopathies were consecutively recruited and sex-matched to healthy controls (HC).
View Article and Find Full Text PDFThe presence of protein aggregates is a hallmark of many neurodegenerative diseases, including Parkinson's disease (PD), Alzheimer's disease (AD), and frontotemporal lobar degeneration (FTLD). Traditionally, each disease has been associated with the aggregation of specific proteins, which serve as disease-specific biomarkers. For example, aggregates of α-synuclein (α-syn) are found in α-synucleinopathies such as PD, dementia with Lewy bodies (DLB), and multiple system atrophy (MSA).
View Article and Find Full Text PDFArticle Synopsis
- Parkinson's disease (PD) is a brain disorder that can cause problems with smell and digestion before the main symptoms appear.
- People with PD often have trouble smelling, swallowing, and digesting food.
- New research suggests that tiny germs in our gut and nose might help cause PD by affecting a protein in the brain called α-synuclein.