Publications by authors named "Ilaria Irodenko"
Postnatal surge of adipose-secreted leptin is a robust predictor of fat mass trajectory in mice.
Am J Physiol Endocrinol Metab
December 2024
Article Synopsis
- The study investigates how a temporary increase in leptin levels after birth, known as leptin surge, may influence future obesity risk in mice, particularly those genetically prone or resistant to obesity.
- The research specifically examines the sources of leptin during this surge and how factors like sex and genetics affect its role in weight gain when placed on different diets.
- Findings reveal that leptin levels at 2 weeks old can predict adult body weight and fat levels, highlighting the importance of early leptin exposure in determining obesity outcomes later in life.
Introduction: Non-alcoholic fatty liver disease (NAFLD) can progress to more severe stages, such as steatohepatitis and fibrosis. Thermoneutral housing together with high-fat diet promoted NAFLD progression in C57BL/6J mice. Due to possible differences in steatohepatitis development between different C57BL/6 substrains, we examined how thermoneutrality affects NAFLD progression in C57BL/6N mice.
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- Long-chain n-3 polyunsaturated fatty acids (Omega-3) and thiazolidinediones (TZDs) work together to combat dietary obesity and related metabolic issues in mice.
- In experiments with mice on a high-fat diet, the combination of Omega-3 and TZDs helped restore the fatty acid cycling process in white adipose tissue (WAT), which was negatively impacted by the diet.
- The study highlights that while both TZDs and Omega-3 have additive effects on metabolism, they influence gene expression and metabolic pathways in different ways.
Article Synopsis
- Omega-3 fatty acids show differing antisteatotic effects in obese rodents based on their lipid form: phospholipids (krill oil) versus triacylglycerols.
- Mice fed with Omega-3 phospholipids (ω3PL-H) experienced significant reductions in body weight gain, fat tissue, and liver lipids compared to those on a high-fat diet alone or those given triacylglycerols (ω3TG).
- Enhanced fatty acid oxidation and gene expression related to lipid metabolism were more prominent in the ω3PL-H group, suggesting that their benefits may stem from improved intestinal fat processing.