Frequency-Selective Microbubble Targeting : A Step Toward Multicolor Ultrasound Molecular Imaging.

Ultrasound molecular imaging (USMI) utilizing targeted microbubbles (tMBs) and primary acoustic radiation force () pulses has demonstrated enhanced sensitivity in recent studies. However, current USMI techniques are limited to a single ligand-receptor pair per imaging scan. With the advent of the buried-ligand architecture (BLA), "cloaked" ligand-receptor binding and tMB adhesion can be activated by pulses, enabling multicolor USMI.