Publications by authors named "Ilaria Adamo"
[reaction: see text] The base-catalyzed hydroazidation of alpha'-amino alpha,beta-unsaturated ketones with in situ generated hydrazoic acid was found to proceed with high stereoselectivity in favor of the syn product. The stereoselectivity is controlled by the configuration of the enone and syn/anti ratios up to 7:1 were obtained with secondary and tertiary amines at low temperature. By this route the diamino alcohol core of HIV-PR inhibitors ritonavir and lopinavir was synthesized in 37% yield from phenylalanine.
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- A new method for making oligonucleotides is introduced, which uses recyclable solid-supported reagents to simplify the process.
- It employs a specific activator (polyvinyl pyridinium tosylate) to facilitate the coupling of nucleosides during synthesis.
- The technique streamlines purification by allowing excess reagents to be easily filtered out, thus eliminating the need for complex purification steps.
Synthesis of oligonucleotide-peptide PEG-conjugated: the EGG (oligonucleotide)-chicken (peptide) dilemma?
Nucleosides Nucleotides Nucleic Acids
December 2003
The synthesis of a peptide-PEG-oligonucleotide chimera is compared when starting from the peptide or from the oligonucleotide sequence.
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