Publications by authors named "Ilanna Loeffel"
Ovarian cancer (OCa) is the deadliest gynecologic cancer. Emerging studies suggest ovarian cancer stem cells (OCSCs) contribute to chemotherapy resistance and tumor relapse. Recent studies demonstrated estrogen receptor beta (ERβ) exerts tumor suppressor functions in OCa.
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- Endometrial cancer (EC) shows abnormal activation of the PI3K/Akt/mTOR signaling pathway, and while mTOR inhibitors have been used in treatment, their effectiveness has been limited.
- Researchers found that inhibiting KDM1A, an epigenetic modifier overexpressed in EC, enhances the effects of mTOR inhibitors, significantly reducing cell viability and migration in cancer cells.
- Studies indicate that KDM1A inhibition reduces activation of the mTOR pathway and related survival signals, suggesting that a combination therapy using both KDM1A and mTOR inhibitors could improve outcomes for EC patients.