[The influence of correction of iron metabolism and erythron characteristics in mild iron deficiency states on clinical manifestations of coronary heart disease].

We studied the influence of correction of iron metabolism and erythron characteristics to normal values in latent iron-deficiency states and mild iron deficiency anemia (IDA) with a hemoglobin level of 130-110 g/l on clinical manifestations of the concomitant coronary heart disease (CHD). The patients were 71 men aged 51.5 +/- 1.

Effects of expression of transcriptional factor AP-1 FOSL1 gene on psoriatic process.

We performed quantitative analysis of FOSL1 gene expression in lesional psoriatic skin. The expression of this gene in lesional psoriatic skin was significantly increased compared to that in unaffected areas. Enhanced FOSL1 expression significantly correlated with high psoriasis area and severity index (PASI).

[Expression of the FOSL1 gene in psoriasis and atherosclerosis].

Psoriatic and atherosclerotic plaques were examined using the real-time polymerase chain reaction. Expression of the FOSL1 gene proved to substantially increase in both psoriatic lesions of the skin and atherosclerotic lesions of vessels as compared with nonlesion samples.

[Antioxidant activity of inhibitors of free radical reactions in the dressing materials for wound healing].

Antioxidant activity (AA) of inhibitors of free radical reactions (FRR) (dieton, mexidol, trypsin), aplied to the dressing material for wound healing was studied. In our work we used a model system containing suspension of laminated liposome, formed from fraction of total chicken yolk phospholipids. Lipid peroxidation (LPO) of liposome membranes was initiated by addition of Fe2+ ions.

Comparative study of antioxidant properties of immunoregulatory peptides.

We studied antioxidant properties of immunofan, bursin, cyclobursin, thymopoietin II fragment, glycine, and Siberian ginseng. Experiments were performed in 2 model systems: Fe(2+)-induced oxidation of multilamellar phospholipid liposomes in a heterogeneous water-lipid system and oxidation of luminol induced by alpha,alpha'-azo-bis(isobutyramidine dihydrochloride) in a homogenous aqueous system. By the ability to entrap lipid peroxyl radicals, antioxidant activity of substances decreased in the following order: Siberian ginseng extract>bursin>cyclobursin>thymopoietin II fragment>immunofan, glycine.

[Infectious diseases in children living under conditions of technology-related pollution of atmospheric air].

Epidemiological and clinical studies in children with acute respiratory viral infections (ARVI) and viral hepatitis A (HVA), living in zones with different levels of technogenic pollution of the atmosphere, showed that the incidence and clinical course of viral infections in children depended on the technogenic pollution of the environment, this effect being the more pronounced, the higher the level of xenobiotics in the air. Children living under conditions of high technogenic pollution of the environment should be regarded as a group at risk of more severe ARVI and HVA with complications.

[Characteristics of acute respiratory viral infections in children under conditions of technogenic environmental pollution].

The results of observations on children with acute virus respiratory infections (ARVI) and who had long been residents of zones with different levels of technogenic pollution of the atmospheric air are presented. The technogenic pollution of the environment has been found to exert influence on the spread and clinical course of ARVI in children, this influence being the more pronounced, the higher is the level of xenobiotics in the atmospheric air. The severity of the disease is noted to depend on the development of a number of syndromes, aggravating the course of ARVI, such as the neurotoxic and bronchoobstructive syndromes.

[Antimicrobial activity of hyaluronic acid].

In this work the biological activity of hyaluronic acid (HA), isolated from fowl crests, is evaluated. The data on the physico-chemical analysis of HA are presented. The preparation obtained is characterized by a high content of the main substance and high relative viscosity.

[Pharmacological prophylaxis of vestibulo-autonomous syndrome (motion sickness) in model investigations].

The authors summarize results of multiyear investigations at the Institute of Biomedical Problems of induced motion sickness and development of prophylactic medicaments representing various classes of biologically active substances (choline blocking agents, sympathomimetics, antihistamines etc.) prescribed singularly or in an combination based on the knowledge of MS-provoking inter-receptor interactions and therapeutic effects of drugs.

[Results of 24-hours arterial blood pressure monitoring in patients with mitral prolapse and anomalous chorda].

Aim: To examine 24-h arterial hypertension (AH) profile in patients with connective tissue dyplasia syndrome (CTDS).

Materials And Methods: 92 patients (35 males and 57 females) with CTDS aged 18-37 years. 68 had mitral prolapse stage I-II, of them 23 had anomalous chorda.

[The pharmacological correction of hemodynamics during the simulation of the early period of adaptation to weightlessness].

Investigations of volunteered subjects in whom antiorthostatic hypokinesia was modeled by tilting the cranial end of the body by -15 degrees were to answer whether pharmacological countermeasures of the vestibular/autonomous syndrome (motion sickness, sea sickness) alter the orthostatic tolerance and cardiovascular parameters. As was stated, the drugs allow controlled correction of hemodynamic resistance to the head-down tilt. Ephedrine, phencarol, ephedrine combined with scopolamine and pipolphen, and stugeron normalized cerebral circulation.

[Functional changes of the cardiovascular system and their pharmacological correction during suited immersion].

In the course of 126 man/exposures of 3 hours to 3 days in duration, in which 39 test subjects took part, circulation responses to the upright and supine body position during suited immersion as well as orthostatic and exercise tolerance after immersion were investigated. During 24 man/exposures for 2 days the subjects were administered per os placebo or one of the four neurotrophic drugs: sydnocarb, sydnogluton, sydstrigluton, estrigluton. Clinical observations, instrumented data and methodical features of the immersion model used give evidence that the suited immersion has advantages over currently used procedures simulating the effects of hypogravity.

[Effect of pertussis antibodies on the induction of suppressor cells of humoral immunity in mice].

Standard pertussis agglutinative serum as well as antibodies to total and purified protective pertussis antigens, isolated from the serum by immunoadsorption technique, were studied. The treatment of donors with pertussis antibodies affected the T-suppressor formation, induced by high doses of sheep red blood cells, as was shown on the model of syngeneic transfer. Immunomodulating effect of antibodies, complementary to immunogen fraction of pertussis cells, was decreased.

[Effect of pharmacological agents to prevent the motion sickness syndrome on the cardiovascular system in simulating the early period of adaptation to weightlessness].

The application of pharmacological agents, preventing the motion sickness syndrome in modelling the early stages of adaptation to weightlessness by means of 6-hour antiorthostatic influence (-15 degrees), does not exert a negative action on the human cardiovascular system. The given agents normalize partially cerebral circulation, eliminating changes induced by antiorthostatic influence.

[Evaluation of the indices of humoral and cellular immunity induced in mice of various genotypes by pertussis antigens].

The genetic predetermination of the level of immune reactions to the injection of corpuscular pertussis vaccine and purified soluble pertussis vaccine has been revealed. Genetic differences in the intensity of immune response are manifest in both humoral and cell-mediated immunity. C57BL/6 mice belong to strains with high responsiveness, while NIHHSFS/H and CBWA mice belong to strains with low responsiveness to Bordetella pertussis.

[Content of biogenic amines and their precursors in human blood during head-down tilt and in taking pharmacological agents to prevent the motion sickness syndrome].

The 6-hour exposure to head-down tilt at --15 degrees was accompanied by an increased blood content of adrenaline and noradrenaline, thus indicating the activation of the sympathoadrenal system. The catecholamine concentration was shown to be proportional to the head-down tilt time. The exposure also led to an increase of the content of serotonin and left the content of 5-hydroxytryptophan, tryptophan, histamine and histidine unchanged.

[Ability of components of pertussis bacteria to induce delayed-type hypersensitivity to DNA].

Bordetella pertussis vaccine contains antigens which are capable to evoke delayed type hypersensitivity (DTH) reactions to deoxyribonucleic acid, except specific antipertussis response in mice. This phenomenon signifies the possibility of the autoimmune process. The purified derivatives of B.

[Induction of antibodies to native DNA by components of Bordetella pertussis].

Administration of Bordetella pertussis and some of their components to mice induced an increase of DNA-binding activity of the sera revealed under ionic strength conditions of physiological saline, mostly on the 14th day. It was shown by the inhibition method that interaction between mouse sera and native DNA was specific. Maximum increase in the quantity of mouse sera proteins reacting with DNA under low ionic strength condition of physiological saline (0.