Publications by authors named "Ikuyo Yoshino"
Article Synopsis
- Programmed cell death is crucial for the growth and balance of multicellular organisms and includes processes like apoptosis and autophagy.
- Researchers found that embryonic fibroblasts from mice lacking both Bax and Bak (DKO mice) can still die via autophagy when stressed, while the newly created mice lacking Atg5 (TKO mice) show significantly reduced autophagy and higher cell viability.
- The study showed that DKO embryos had delays in a specific developmental feature, and brain malformations appeared in TKO embryos, suggesting that autophagy plays a vital role in compensating for the absence of apoptosis during embryonic development.
Background: Histone deacetylase (HDAC) inhibitors are immunomodulatory, and demonstrate antitumor activity in various tumor models including malignant melanoma.
Objective: The present study examines the effectiveness of IL-2 and HDAC inhibitor MS-275-combination therapy in a murine melanoma model.
Methods: B16F10 cells were implanted subcutaneously in C57BL/6 mice which were randomly divided into four groups and treated with either IL-2 by subcutaneous injection, MS-275 by oral gavage (5 days/week, daily for 2 weeks), or a combination of the two agents.
IL-10-deficient mice spontaneously develop intestinal inflammation, which has many similarities to Crohn's disease. Several reports suggest that epithelial cell death may increase the severity of colitis; however, decisive evidence is lacking. In the present report, we addressed whether and how epithelial cell death plays a role in the development of chronic colitis.
View Article and Find Full Text PDFNon-small cell lung cancer (NSCLC) is a major subtype of lung cancer and is the most common and fatal cancer worldwide. Specific tyrosine kinase inhibitors for epidermal growth factor receptor (EGFR), such as gefitinib, have been effective in some NSCLC patients and are being used in the clinical setting as pioneer molecularly targeted cancer drugs. However, many patients have not responded to these drugs, and have acquired resistance after long-term treatment.
View Article and Find Full Text PDFBackground: 5-Aminolevulinic acid (5-ALA) is a precursor of a tetrapyrrole compound. 5-ALA has been used for photodynamic therapy as well as for plant growth. 5-ALA and iron ion are precursors of heme, which is incorporated into hemoglobin and cytochrome.
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