Publications by authors named "Ikuyo Oshima"
Article Synopsis
- - The study aimed to evaluate the safety of l-lysine supplementation in diets, revealing a lack of comprehensive safety data despite its common use in supplements.
- - After reviewing 71 articles involving 3,357 participants, the main adverse effects noted were gastrointestinal symptoms, but these were not statistically significant.
- - A provisional no-observed-adverse-effect level was determined to be 6.0 g per day for healthy individuals, based on the gastrointestinal symptoms reported.
Currently, the use of amino acids in supplements and functional foods is increasing globally. However, there are no guidelines for the upper limit of ingestion for the safe use of these amino acids. Safety evaluation of chemical substances is generally performed through non-clinical and clinical studies.
View Article and Find Full Text PDF