Prevalence of endoscopically negative and positive gastroesophageal reflux disease in the Japanese.

Objective: The frequency of gastroesophageal reflux disease (GERD) has not been fully investigated in the Asian population. The aim of this study was to investigate the prevalence of GERD, endoscopy-negative GERD (NERD), and erosive GERD in Japan, and the factors influencing disease prevalence.

Materials And Methods: A total of 2760 subjects (mean age 50.